Identification of long-term therapeutic strategy in IgE-mediated allergy by leveraging humanized models and patient samples

Project Information

HumanIgE

Grant agreement ID: 101043749

DOI

10.3030/101043749

EC signature date 2 May 2022

Start date 1 March 2023

End date 29 February 2028

Funded under

• European Research Council (ERC)

Total cost

€ 1 999 431,00

EU contribution

€ 1 999 431,00

Coordinated by

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (9)

Journal of Allergy and Clinical Immunology

Author(s): Derek Croote; Joyce J.W. Wong; Cyprien Pecalvel; Edouard Leveque; Natacha Casanovas; Jasper B.J. Kamphuis; Paige Creeks; Johanna Romero; Saba Sohail; Daniel Bedinger; Kari C. Nadeau; Rebecca S. Chinthrajah; Laurent L. Reber; Henry B. Lowman
Published in: Journal of Allergy and Clinical Immunology, 2024, ISSN 0091-6749
Publisher: Mosby Inc.
DOI: 10.1016/J.JACI.2023.08.035

An Anti‐IL‐13 Vaccine Reduces Atopic Dermatitis in Humanized Mice and Induces Neutralizing Antibodies in Nonhuman Primates

Author(s): Aurélie Mougel, Katia Lemdani, Nadine Serhan, Charlotte Hateb, Jonathan Bonnefoy, Samir Hamdi, William P. M. Worrall, Jasper B. J. Kamphuis, Léna Andrieux, Fabien Colaone, Rémi Vieira, Margot Zahm, Adeline Chaubet, Simon Lachambre, Rüçhan Ekren, Edouard Leveque, Laurent Guilleminault, Nicolas Gaudenzio, Béatrice Drouet, Vincent Serra, Laurent L. Reber
Published in: Allergy, 2025, ISSN 0105-4538
Publisher: Wiley
DOI: 10.1111/ALL.70110

Tissue Distribution and Phenotype of Human Mast Cells in <scp>BRGSF</scp> and <scp>NSG</scp>‐<scp>SGM3</scp>‐<scp>IL15</scp> Humanized Mice

Author(s): William P. M. Worrall, Nadine Serhan, Julien J. Karrich, Céline El Samrout, Ruchan Ekren, Jasper B. J. Kamphuis, Charlotte Hateb, Edouard Leveque, Alexia Loste, Pol Andre Apoil, Nicolas Gaudenzio, Laurent L. Reber
Published in: Allergy, 2025, ISSN 0105-4538
Publisher: Wiley
DOI: 10.1111/ALL.70058

Allergy: European Journal of Allergy and Clinical Immunology

Author(s): Charles, Nicolas; Kortekaas-Krohn, Inge; Kocaturk, Emek; Scheffel, Jörg; Altrichter, Sabine; Steinert, Carolin; Xiang, Yi Kui; Gutermuth, Jan; Reber, Laurent L.; Maurer, Marcus
Published in: Allergy, 2023, ISSN 0105-4538
Publisher: Wiley
DOI: 10.1111/ALL.15843

LuLIPLEX: A Fast, Highly Sensitive, and Multiplexed Method for the Detection of IgE Against Major Allergens

Author(s): Edouard Leveque, Cyprien Pecalvel, Natacha Casanovas, Sophie Goyard, Yves L. Janin, Thierry Rose, Benjamin Trouche‐Estival, Pol André Apoil, Marine Michelet, Laurent Guilleminault, Laurent L. Reber
Published in: Allergy, Issue 80, 2025, ISSN 0105-4538
Publisher: Wiley
DOI: 10.1111/ALL.16403

A vaccine targeting human IgE induces long-term protection against anaphylaxis in humanized mice

Author(s): Eva Conde, Emma Lamanna, Aurélie Mougel, Jasper B. J. Kamphuis, Alexia Loste, Julien Stackowicz, Ophélie Godon, Emilie Mauré, Cyprien Pecalvel, William P. M. Worrall, Léna Andrieux, Edouard Levequ
Published in: Science Translational Medicine, Issue 17, 2025, ISSN 1946-6234
Publisher: American Association for the Advancement of Science (AAAS)
DOI: 10.1126/SCITRANSLMED.ADS0982

Aging Increases the Severity of Anaphylaxis Through Changes in Mast Cell Numbers and Histamine Sensitivity

Author(s): Jasper B. J. Kamphuis, Alexia Loste, William P. M. Worrall, Nadine Serhan, Thomas Villeneuve, Pol André Apoil, Benjamin Trouche‐Estival, null null, Laurent Guilleminault, Nicolas Gaudenzio, Laurent L. Reber
Published in: Allergy, Issue 80, 2025, ISSN 0105-4538
Publisher: Wiley
DOI: 10.1111/ALL.16650

Allergy: European Journal of Allergy and Clinical Immunology

Author(s): Cyprien Pecalvel; Aurélie Mougel; Edouard Leveque; Katia Lemdani; Vincent Serra; Laurent Guilleminault; Laurent L. Reber
Published in: Allergy, 2024, ISSN 0105-4538
Publisher: Wiley
DOI: 10.1111/ALL.16367

Development of a Conjugate Vaccine Targeting Human <scp>IgE</scp> for Long‐Term Prevention of Anaphylaxis

Author(s): Vincent Serra, Laurent L. Reber
Published in: Allergy, 2025, ISSN 0105-4538
Publisher: Wiley
DOI: 10.1111/ALL.70099