Objective
The implantation of the blastocyst into the uterine wall is a key step of the reproductive cycle, which mediates the connection of the embryo to the maternal tissues during the early stages of pregnancy. However, in some species, including the house mouse, this process can be put on hold, while the embryo falls into a reversible state of suspended animation, known as diapause. The dormant embryos can reside in a “deep sleep” over extended periods of time (e.g. bypassing unfavourable environmental conditions), without compromising their developmental potential. Although, the maternal hormonal control of implantation and the process of transient mouse embryogenesis have been intensively studied, the embryonic diapause is still an extremely enigmatic state. Several lines of evidence, based on my preliminary data, suggest that diapause is not a stasis, but instead is a dynamic process with underlying mechanisms that can appear redundant during transient embryogenesis. Here I aim to decipher the cryptic embryo-intrinsic mechanisms of embryo dormancy, using the mouse as a model system. I will elucidate the cellular processes that coordinate and capacitate the embryo for diapause on epigenetic, transcriptional and cell signalling levels. Using interspecies chimeras and blastoids, I will extend my analysis to non-diapausing species and artificial embryo-like structures. Thus, by manipulating the flow of embryogenesis, I will uncover hidden, dormant mechanisms, safeguarding the developmental potential of the early mammalian embryo.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences developmental biology
- medical and health sciences clinical medicine obstetrics
- medical and health sciences clinical medicine embryology
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.1 - European Research Council (ERC)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-ERC - HORIZON ERC Grants
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) ERC-2021-COG
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
80539 MUNCHEN
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.