Mechanisms at the interface of DNA damage repair and transcription

Project Information

STOP-FIX-GO

Grant agreement ID: 101043815

DOI

10.3030/101043815

EC signature date 23 May 2022

Start date 1 June 2022

End date 31 May 2027

Funded under

• European Research Council (ERC)

Total cost

€ 1 999 764,00

EU contribution

€ 1 999 764,00

Coordinated by

ACADEMISCH ZIEKENHUIS LEIDEN
Netherlands

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Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Documents, reports (1)

Data Management Plan

Publications

Peer reviewed articles (7)

Structural basis for RNA pol II ubiquitylation and inactivation in transcription-coupled repair

Author(s): Kokic G, Yakoub G, van den Heuvel D, Wondergem AP, van der Meer PJ, van der Weegen Y, Chernev A, Fianu I, Fokkens TJ, Lorenz S, Urlaub H, Cramer P, Luijsterburg MS.
Published in: Nature structural & molecular biology, 2024, ISSN 1545-9985
Publisher: Nature
DOI: 10.1038/s41594-023-01207-0

A disease-associated XPA allele interferes with TFIIH binding and primarily affects transcription-coupled nucleotide excision repair

Author(s): Van den Heuvel D, Kim M, Wondergem AP, Van der Meer PJ, Witkamp M, Lambregtse F, Kim HS, Kan F, Apelt K, Kragten A, González-Prieto R, Vertegaal ACO, Yeo J-E, Kim B-G, Van Doorn R, Schärer OD, Luijsterburg MS
Published in: Proceedings of the National Academy of Sciences, 2023, ISSN 1091-6490
Publisher: The National Academy of Sciences (NAS)
DOI: 10.1073/PNAS.2208860120

Unscheduled DNA synthesis at sites of local UV-induced DNA damage to quantify global genome nucleotide excision repair activity in human cells

Author(s): Van der Meer PJ, van den Heuvel D, Luijsterburg MS
Published in: Bio-protocol, 2023, ISSN 2331-8325
Publisher: Bio-protocol
DOI: 10.21769/BioProtoc.4609

STK19 facilitates the clearance of lesion-stalled RNAPII during transcription-coupled DNA repair

Author(s): Diana van den Heuvel, Marta Rodríguez-Martínez, Paula J. van der Meer, Nicolas Nieto Moreno, Jiyoung Park, Hyun-Suk Kim, Janne J.M. van Schie, Annelotte P. Wondergem, Areetha D’Souza, George Yakoub, Anna E. Herlihy, Krushanka Kashyap, Thierry Boissière, Jane Walker, Richard Mitter, Katja Apelt, Klaas de Lint, Idil Kirdök, Mats Ljungman, Rob M.F. Wolthuis, Patrick Cramer, Orlando D. Schärer, Goran Kokic, Jesper Q. Svejstrup, Martijn S. Luijsterburg
Published in: Cell, Issue 187, 2024, ISSN 0092-8674
Publisher: Elsevier BV
DOI: 10.1016/j.cell.2024.10.018

EXO1-mediated DNA repair by single-strand annealing is essential for BRCA1-deficient cells

Author(s): van de Kooij B, Schreuder A, Pavani RS, Garzero V, Uruci S, Wendel TJ, Van Hoeck A, Everts M, San Martin Alonso M, Koerse D, Callen E, Boom J, Mei H, Cuppen E, Luijsterburg MS, Van Vugt MATM, Nussenzweig A, van Attikum H, Noordermeer SM.
Published in: Molecular cell, 2024, ISSN 1097-4164
Publisher: Cell
DOI: 10.1016/j.molcel.2023.12.039

Evidence that ARK2N is not a core factor in transcription-coupled DNA repair

Author(s): Janne J. M. van Schie, Sem J. Brussee, Martijn S. Luijsterburg
Published in: Proceedings of the National Academy of Sciences, Issue 122, 2025, ISSN 0027-8424
Publisher: Proceedings of the National Academy of Sciences
DOI: 10.1073/pnas.2425178122

Cockayne syndrome proteins CSA and CSB promote transcription-coupled repair of DNA-protein crosslinks independently of nucleotide excision repair

Author(s): Carnie CJ, Acampora AC, Bader AS, Erdenebat C, Zhao S, Bitensky E, van den Heuvel D, Parnas A, Gupta V, D’Alessandro G, Sczaniecka-Clift M, Weickert P, Aygenli F, Götz MJ, Cordes J, Esain-Garcia I, Melidis L, Wondergem AP, Lam S, Robles MS, Balasubramania
Published in: Nature cell biology, 2024, ISSN 1476-4679
Publisher: Nature
DOI: 10.1111/acel.13268