Objective The 2020 update of the European Strategy for Particle Physics puts the HL-LHC at the focal point, “together with continued innovation in experimental techniques”. Its primary goals include searching for new physics at high energy, exploration of the Higgs potential and precision tests of the Standard Model.At a hadron collider such as LHC, practically all measurements rely on jet energy corrections (JEC). Many important benchmark channels, such as top quark decaying to b jets and ud or cs jet pairs and inclusive jets produced with numerous gluon jets, have JEC as their limiting uncertainty. At present, the JEC uncertainties are at a level of 1% overall, with similar additional uncertainties from flavor-specific JEC from simulation only.However, evidence suggests that the simulation is biased at the level of these uncertainties, and that these biases will become the decisive factor for further progress. Here we show how to correct these biases with data-driven methods and bring the total uncertainties toward 0.1% level.We found that with integrated luminosity of more than 100/fb, the Z+flavor channel can be used to precisely measure all flavor-JEC, when combined with our novel techniques to address flavor-dependent biases from initial and final state radiation, underlying event and heavy-flavor neutrino production. Furthermore, we found that inclusive jet production can be used to monitor further drifts of JEC at 0.1% precision and that our observations can be motivated with a parameterized model of particle flow jet response.Our results plot a path to JEC at the HL-LHC high pileup environment, and show how to systematically control the leading simulation uncertainties with data and allow many physics analyses to improve their JEC-related systematic uncertainties.We anticipate our work will be a starting point to transition to 0.1%-level precision in JEC across the field and that it will lead to a number of precision jet physics measurements as a result. Fields of science natural sciencesphysical sciencestheoretical physicsparticle physicsneutrinosnatural sciencesphysical sciencestheoretical physicsparticle physicsparticle acceleratornatural sciencesphysical sciencestheoretical physicsparticle physicsgluonsnatural sciencesphysical sciencestheoretical physicsparticle physicsquarks Programme(s) HORIZON.1.1 - European Research Council (ERC) Main Programme Topic(s) ERC-2021-COG - ERC CONSOLIDATOR GRANTS Call for proposal ERC-2021-COG See other projects for this call Funding Scheme ERC - Support for frontier research (ERC) Coordinator HELSINGIN YLIOPISTO Net EU contribution € 1 955 918,00 Address Yliopistonkatu 3 00014 Helsingin yliopisto Finland See on map Region Manner-Suomi Helsinki-Uusimaa Helsinki-Uusimaa Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00