Letting up senescence and inflammaging through T cells

Project Information

Let T Be

Grant agreement ID: 101044248

DOI

10.3030/101044248

EC signature date 12 December 2022

Start date 1 March 2023

End date 29 February 2028

Funded under

• European Research Council (ERC)

Total cost

€ 1 999 944,00

EU contribution

€ 1 999 944,00

Coordinated by

AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS
Spain

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (7)

CD4 T cell therapy counteracts inflammaging and senescence by preserving gut barrier integrity

Author(s): Manuel M. Gómez de las Heras, Elisa Carrasco, Mario Pérez-Manrique, Naohiro Inohara, Sandra Delgado-Pulido, Álvaro Fernández-Almeida, María I. Gálvez-Castaño, Isaac Francos-Quijorna, Carolina S
Published in: Science Immunology, Issue 10, 2025, ISSN 2470-9468
Publisher: American Association for the Advancement of Science (AAAS)
DOI: 10.1126/SCIIMMUNOL.ADV0985

Everything everywhere all at once: Unraveling the waves of aging

Author(s): Jose Ignacio Escrig-Larena, María Mittelbrunn
Published in: Immunity, Issue 58, 2025, ISSN 1074-7613
Publisher: Elsevier BV
DOI: 10.1016/J.IMMUNI.2025.01.015

Mitochondria during T cell aging

Author(s): Jose Ignacio Escrig-Larena, Sandra Delgado-Pulido, María Mittelbrunn
Published in: Seminars in Immunology, Issue 69, 2024, ISSN 1044-5323
Publisher: Elsevier BV
DOI: 10.1016/J.SMIM.2023.101808

Old T cells pollute with mito-litter

Author(s): Manuel M. Gómez de las Heras; María Mittelbrunn
Published in: Nature Aging, 2023, ISSN 2662-8465
Publisher: Springer Nature
DOI: 10.1038/S43587-023-00412-2

KLRG1 identifies regulatory T cells with mitochondrial alterations that accumulate with aging

Author(s): Gonzalo Soto-Heredero, Enrique Gabandé-Rodríguez, Elisa Carrasco, José Ignacio Escrig-Larena, Manuel M. Gómez de las Heras, Sandra Delgado-Pulido, Isaac Francos-Quijorna, Eva M. Blanco, Álvaro Fe
Published in: Nature Aging, Issue 5, 2025, ISSN 2662-8465
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/S43587-025-00855-9

Inflammageing, a targetable pathway for preventing cardiovascular diseases

Author(s): Juan Francisco Aranda, Cristina M Ramírez, María Mittelbrunn
Published in: Cardiovascular Research, Issue 121, 2025, ISSN 0008-6363
Publisher: Oxford University Press (OUP)
DOI: 10.1093/CVR/CVAE240

Sexual dimorphism in the antitumor immune responses elicited by the combination of fasting and chemotherapy

Author(s): Andrés Pastor‐Fernández, Manuel Montero Gómez de las Heras, Jose Ignacio Escrig‐Larena, Marta Barradas, Cristina Pantoja, Adrian Plaza, Jose Luis Lopez‐Aceituno, Esther Durán, Alejo Efeyan,
Published in: Cancer Communications, Issue 44, 2024, ISSN 2523-3548
Publisher: Wiley
DOI: 10.1002/CAC2.12535