Determining the mechanisms of lipid-targeting antibiotics in intact bacteria

Project Information

champANTIBIOTICS

Grant agreement ID: 101045485

DOI

10.3030/101045485

EC signature date 25 May 2022

Start date 1 June 2022

End date 31 May 2027

Funded under

• European Research Council (ERC)

Total cost

€ 2 000 000,00

EU contribution

€ 2 000 000,00

Coordinated by

UNIVERSITEIT UTRECHT
Netherlands

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Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (6)

Sophisticated natural products as antibiotics

Author(s): Kim Lewis, Richard E. Lee, Heike Brötz-Oesterhelt, Sebastian Hiller, Marina V. Rodnina, Tanja Schneider, Markus Weingarth,Ingo Wohlgemuth
Published in: Nature, 2024, ISSN 1476-4687
Publisher: Nature
DOI: 10.1038/s41586-024-07530-w

Host defence peptide plectasin targets bacterial cell wall precursor lipid II by a calcium-sensitive supramolecular mechanism

Author(s): Shehrazade Jekhmane, Maik G. N. Derks, Sourav Maity, Cornelis J. Slingerland, Kamaleddin H. M. E. Tehrani, João Medeiros-Silva, Vicky Charitou, Danique Ammerlaan, Céline Fetz, Naomi A. Consoli, Rachel V. K. Cochrane, Eilidh J. Matheson,..Markus Weingarth
Published in: Nature Microbiology, 2024, ISSN 2058-5276
Publisher: Nature
DOI: 10.1038/s41564-024-01696-9

An antibiotic from an uncultured bacterium binds to an immutable target

Author(s): Rhythm Shukla, Aaron J. Peoples, Kevin C. Ludwig, Sourav Maity, Maik G.N. Derks, Stefania De Benedetti, Annika M. Krueger, Bram J.A. Vermeulen, Theresa Harbig, Francesca Lavore, Raj Kumar, Rodrigo V. Honorato, Fabian Grein, Kay Nieselt, Yangping Liu, Alexandre M.J.J. Bonvin, Marc Baldus, Ulrich Kubitscheck, Eefjan Breukink, Catherine Achorn, Anthony Nitti, Christopher J. Schwalen, Amy L. Spoering, Losee Lucy Ling, Dallas Hughes, Moreno Lelli, Wouter H. Roos, Kim Lewis, Tanja Schneider, Markus Weingarth
Published in: Cell, Issue 186, 2023, ISSN 0092-8674
Publisher: Elsevier BV
DOI: 10.1016/j.cell.2023.07.038

Cooperative Gating of a K+ Channel by Unmodified Biological Anionic Lipids Viewed by Solid-State NMR Spectroscopy

Author(s): Maryam YekefallahEvan J. van AalstRoy A. M. van BeekveldIsaac R. EasonEefjan BreukinkMarkus Weingarth, Benjamin J. Wylie
Published in: JACS, 2024, ISSN 1520-5126
Publisher: JACS
DOI: 10.1021/jacs.3c09266

Teixobactin kills bacteria by a two-pronged attack on the cell envelope

Author(s): Rhythm Shukla, Francesca Lavore, Sourav Maity, Maik G. N. Derks, Chelsea R. Jones, Bram J. A. Vermeulen, Adéla Melcrová, Michael A. Morris, Lea Marie Becker, Xiaoqi Wang, Raj Kumar, João Medeiros-Silva, Roy A. M. van Beekveld, Alexandre M. J. J. Bonvin, Joseph H. Lorent, Moreno Lelli, James S. Nowick, Harold D. MacGillavry, Aaron J. Peoples, Amy L. Spoering, Losee L. Ling, Dallas E. Hughes, Wouter H. Roos, Eefjan Breukink, Kim Lewis, Markus Weingarth
Published in: Nature, Issue 608, 2022, ISSN 0028-0836
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/s41586-022-05019-y

Coordination of bilayer properties by an inward-rectifier K+ channel is a cooperative process driven by protein-lipid interaction

Author(s): Evan J. van Aalst, Maryam Yekefallah, Roy A. M. van Beekveld, Eefjan Breukink, Markus Weingarth, Benjamin J. Wylie
Published in: Journal of Structural Biology: X, 2024, ISSN 2590-1524
Publisher: Elsevier
DOI: 10.1016/j.yjsbx.2024.100101