Objective
Variants of concern (VoC) of SARS-CoV-2 raise the possibility of increases in transmissibility, severity and immune evasion. Children and pregnant women who have not been prioritised in the pandemic, are likely to be the last population for whom vaccines are approved and may have low uptake, increasing the risk of VoC arising in this population. Monitoring this group across regions is crucial given rapid changes in epidemiology due to interventions, vaccine rollout and viral evolution. VERDI (SARS-CoV-2 variants Evaluation in pRegnancy and paeDIatrics cohorts) will build on a long-standing infectious disease research and trial network (Penta) to address research questions on the impact of VoC in these vulnerable groups.
Mpox virus (known as monkeypox or MPX, when this application was originally written) is a zoonotic Orthopox virus first described in the Democratic Republic of Congo (DRC) in 1970. It is an infection of global significance, with cases reported in 11 African countries and sporadic cases reported outside Africa as a result of zoonotic transmission and travellers returning from endemic areas. However, despite the global burden of mpox disease, research into mpox has historically been neglected. This current outbreak of mpox is, like many communicable and non-communicable diseases, a complex biosocial phenomenon, disproportionately impacting marginalised communities, whilst exposing and amplifying global health inequities.
Since May 2022, large numbers of mpox cases have been reported in non-endemic countries. As of 9 September 2022, there have been 57,527 confirmed cases of mpox since the start of the 2022 outbreak, with the vast majority being reported in non-endemic countries. Of the 103 countries reporting cases in this current outbreak, 96 are countries which have not historically reported mpox cases. A recently published case series of 528 patients in 16 countries, reported that 98% of cases were in gay or bisexual men, with 41% also living with HIV. Sexual contact has been found to be the dominant method of transmission in this current outbreak. In this case series, 13% of cases were hospitalised, mainly for pain management, bacterial super-infection, and fluid management. More recently there has been an ongoing mpox outbreak in DRC, mainly affecting children <15 years of age.
VERDI’s objectives are: i) track and characterise VoC and mpox in paediatric and pregnant populations and other high risk populations across the globe;
ii) understand effects of VoC and mpox on clinical outcomes (short/longer term), vaccine effectiveness and transmission characteristics; iii) model outcomes and impacts of VoC and mpox; iv) develop evidence-based recommendations for control of COVID-19 and mpox and other emerging or re-emerging infections.
VERDI will achieve these objectives by bringing together a diverse range of cohort studies including large scale national and regional level population-based cohort studies from the EU and beyond, providing a unique opportunity for harmonised analysis of data on VoC and mpox from a range of sources (e.g. electronic health records, bespoke cohort studies, household transmission studies, screening programmes). We will facilitate expansion of existing studies, e.g. replicating ongoing European household studies elsewhere. Through this approach, VERDI will expand and enhance existing cohort networks, including promoting flexibility to adapt to future emerging infections. The project will improve understanding of the epidemiology and impact of VoC and mpox, leading to robust recommendations for control in a range of global settings as well as developing preparedness for future health emergencies.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
This project's classification has been validated by the project's team.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
This project's classification has been validated by the project's team.
- medical and health sciences health sciences public health epidemiology
- medical and health sciences health sciences infectious diseases RNA viruses coronaviruses
- medical and health sciences basic medicine pharmacology and pharmacy pharmaceutical drugs vaccines
- medical and health sciences clinical medicine obstetrics
- medical and health sciences clinical medicine paediatrics
Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.2.1 - Health
MAIN PROGRAMME
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HORIZON.2.1.4 - Infectious Diseases, including poverty-related and neglected diseases
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-RIA - HORIZON Research and Innovation Actions
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-HLTH-2021-CORONA-01
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
35122 PADOVA
Italy
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Participants (32)
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WC1E 6BT LONDON
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3584 CX Utrecht
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0313 Oslo
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10126 Torino
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67663 Kaiserslautern
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75654 PARIS
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10400 Bangkok
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50200 CHIANG MAI
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37129 Verona
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35127 PADOVA
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6110 Port-Au-Prince
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7701 Rondebosch
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7600 Stellenbosch
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38122 Trento
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5252247 Ramat Gan
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3500 Hasselt
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35020 LEGNARO
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2000 Antwerpen
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4051 Basel
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Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.
Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
4056 Basel
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SW7 2AZ London
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22006 Nicosia
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1000 Bruxelles / Brussel
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900107 Abuja
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The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.
Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
28046 MADRID
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
28041 MADRID
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The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.
Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.
Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
28007 MADRID
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The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.
Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.
Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
28046 Madrid
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4000 LIEGE
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35138 Padova
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51005 TARTU
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N/A KINSHASA
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Partners (1)
Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
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32611 5500 Gainesville
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