Project description
Strategies to stop the asthma and allergy epidemic
Asthma affects both children and adults. However, it is the most common chronic disease among children. It is estimated that one in 10 school-age children suffer from asthma. Allergies are also very prevalent, with up to 50 % of children being diagnosed with them. Unfortunately, there is no cure or effective prevention available. The ERC-funded APROSUS project will advance the field of microbiome research towards in-depth characterisation of microbe-derived metabolite complexes to better understand their associated asthma and allergy protective properties. Project work will be based on previous studies carried out by the team, whereby both asthma and allergies were explored together, identifying relevant taxa of the environmental microbiome and discovering microbiome-derived functional agents conferring protection.
Objective
Asthma and allergies are the epidemic of the 21st century after a sharp rise in prevalence since the middle of the last century. Asthma is the most common chronic condition for children – at school age about every 10th pupil is affected in westernized countries. Likewise, allergic illnesses are very prevalent with 30- 50 % of the paediatric population being affected. Currently, there is neither cure nor effective prevention. However, asthma and allergies are illnesses, which are largely environmentally determined. Exposures to the environmental microbiome greatly determine risk and protection from onset of illness in populations of common genetic make-up. My team and I have described relevant taxa of the environmental microbiome in the unique farm studies we pioneered. Very recently, we discovered the microbiome-derived functional agents conferring protection. These epidemiological findings while being scientifically cutting edge, cannot be back translated to children’s and their families’ benefit. My vision is thus to move the field of microbiome research forward towards in depth characterization of microbe-derived metabolite complexes to better understand their associated asthma- and allergy protective properties by advancing both the experimental and the human population-based studies. The interdisciplinary APROSUS Project addresses this research gap. The aims are to characterize and synthetize these functional agents (aim 1), to understand the underlying mechanisms of protection (aim 2) and to validate the findings in the population-based farm studies (aim 3). Thereby we will lay the ground for translation into innovative and effective prevention strategies to stop the asthma and allergy epidemic.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.1 - European Research Council (ERC)
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Topic(s)
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-ERC - HORIZON ERC Grants
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) ERC-2021-ADG
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85764 Neuherberg
Germany
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