Objective
Plants display an unparalleled regenerative capacity that is widely exploited in modern agriculture, where elite genotypes are asexually multiplied through stem cuttings. A critical point for this successful propagation entails the development of new roots. Unfortunately, the regenerative potential of plants is not universal as many economically and ecologically important species display poor de novo rooting. In my lab we demonstrated that the regenerative potential of plants is the result of a synergistic reaction of two independent wound responses: (1) the accumulation of the phytohormone auxin and (2) the transcriptional activation of stem cell-inducing transcription factors. Follow-up work showed that the latter are specifically activated by pectin-dependent cell wall changes, driving de novo root formation. In UNROPO, we will elucidate this process to UNlock the ROoting POtential of poorly regenerating trees to broaden the spectrum of plant species that can be propagated through cuttings. Through a systematic knockout of pectin modifying and degrading enzymes, combined with metabolic profiling, we aim to identify wound-induced, pectin-derived oligogalacturonides (OGs) that trigger a regeneration response. Downstream OG signal-transducing proteins will be identified through forward genetics experiments and an innovative in-house developed epitope-based single-cell sequencing method. Independently, we will link the regenerative potential of a collection of 250 poplar trees with their pectin metabolome and use genome-wide association studies to pinpoint the underlying pectin modifying, degrading and signaling genes. Ultimately, the obtained results will be used to modify in poorly regenerating tree species the genes involved in the production of regeneration-competent pectin variants, their derived wound-induced OG, and signaling molecules, to unlock the de novo rooting potential, in such manner contributing to the biodiversity of commercial plantations.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry metabolomes
- natural sciences biological sciences ecology ecosystems
- agricultural sciences agriculture, forestry, and fisheries agriculture
- natural sciences biological sciences biochemistry biomolecules proteins enzymes
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.1 - European Research Council (ERC)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-ERC - HORIZON ERC Grants
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) ERC-2021-ADG
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
9052 ZWIJNAARDE - GENT
Belgium
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.