Solving the dynamic range problem of hearing: deciphering and harnessing cochlear mechanisms of sound intensity coding

Project Information

DynaHear

Grant agreement ID: 101054467

DOI

10.3030/101054467

EC signature date 10 May 2022

Start date 1 January 2023

End date 31 December 2027

Funded under

• European Research Council (ERC)

Total cost

€ 2 499 411,25

EU contribution

€ 2 499 411,00

Coordinated by

UNIVERSITAETSMEDIZIN GOETTINGEN - GEORG-AUGUST-UNIVERSITAET GOETTINGEN - STIFTUNG OEFFENTLICHEN RECHTS
Germany

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (10)

Bridging the gap between presynaptic hair cell function and neural sound encoding

Author(s): Lina María Jaime Tobón, Tobias Moser
Published in: eLife, Issue 12, 2024, ISSN 2050-084X
Publisher: eLife Sciences Publications, Ltd
DOI: 10.7554/ELIFE.93749.4

SynapseNet: Deep Learning for Automatic Synapse Reconstruction

Author(s): Sarah Muth, Frederieke Moschref, Luca Freckmann, Sophia Mutschall, Ines Hojas-Garcia-Plaza, Julius N. Bahr, Arsen Petrovic, Thanh Thao Do, Valentin Schwarze, Anwai Archit, Kirsten Weyand, Susann Michanski, Lydia Maus, Cordelia Imig, Anika Hintze, Nils Brose, Carolin Wichmann, Ruben Fernandez-Busnadiego, Tobias Moser, Silvio O. Rizzoli, Benjamin H. Cooper, Constantin Pape
Published in: Molecular Biology of the Cell, 2025, ISSN 1059-1524
Publisher: American Society for Cell Biology (ASCB)
DOI: 10.1091/MBC.E24-11-0519

Gating of hair cell Ca ²⁺ channels governs the activity of cochlear neurons

Author(s): Nare Karagulyan, Anupriya Thirumalai, Susann Michanski, Yumeng Qi, Qinghua Fang, Haoyu Wang, Nadine J. Ortner, Jörg Striessnig, Nicola Strenzke, Carolin Wichmann, Yunfeng Hua, Tobias Moser
Published in: Science Advances, Issue 11, 2025, ISSN 2375-2548
Publisher: American Association for the Advancement of Science (AAAS)
DOI: 10.1126/SCIADV.ADU7898

Ca ²⁺ regulation of glutamate release from inner hair cells of hearing mice

Author(s): Lina María Jaime Tobón; Tobias Moser
Published in: Proceedings of the National Academy of Sciences, 2023, ISSN 1091-6490
Publisher: National Academy of Sciences
DOI: 10.1073/PNAS.2311539120

Theranostics

Author(s): Anupriya Thirumalai; Jana Henseler; Marzieh Enayati; Kathrin Kusch; Roland Hessler; Tobias Moser; Antoine Tarquin Huet
Published in: Theranostics, 2024, ISSN 1838-7640
Publisher: Ivyspring Int. Publ.
DOI: 10.1101/2024.10.12.617982

Synaptic activity is not required for establishing heterogeneity of inner hair cell ribbon synapses

Author(s): Nare Karagulyan, Tobias Moser
Published in: Frontiers in Molecular Neuroscience, Issue 16, 2023, ISSN 1662-5099
Publisher: Frontiers Media SA
DOI: 10.3389/FNMOL.2023.1248941

Probing the role of synaptic adhesion molecule RTN4RL2 in setting up cochlear connectivity

Author(s): Nare Karagulyan, Maja Überegger, Yumeng Qi, Norbert Babai, Florian Hofer, Lejo Johnson Chacko, Fangfang Wang, Maria Luque, Rudolf Glueckert, Anneliese Schrott-Fischer, Yunfeng Hua, Tobias Moser, Christine Bandtlow
Published in: eLife, Issue 14, 2025, ISSN 2050-084X
Publisher: eLife Sciences Publications, Ltd
DOI: 10.7554/ELIFE.103481.3

Piccolino is required for ribbon architecture at cochlear inner hair cell synapses and for hearing

Author(s): Susann Michanski; Rohan Kapoor; Anna M Steyer; Wiebke Möbius; Iris Früholz; Frauke Ackermann; Mehmet Gültas; Craig C Garner; F Kent Hamra; Jakob Neef; Nicola Strenzke; Tobias Moser; Carolin Wichmann
Published in: EMBO reports, 2023, ISSN 1469-3178
Publisher: EMBO Press
DOI: 10.15252/EMBR.202256702

Combinatorial transcriptional regulation establishes subtype-appropriate synaptic properties in auditory neurons

Author(s): Isle Bastille, Lucy Lee, Cynthia Moncada-Reid, Wei-Ming Yu, Austen Sitko, Andrea Yung, Mina Zamani, Nele Christophersen, Reza Maroofian, Hamid Galehdari, Norbert Babai, Barbara Vona, Tobias Moser, Lisa Goodrich
Published in: Cell Reports, Issue 44, 2025, ISSN 2211-1247
Publisher: Elsevier BV
DOI: 10.1016/J.CELREP.2025.115796

Diversity matters — extending sound intensity coding by inner hair cells via heterogeneous synapses

Author(s): Tobias Moser; Nare Karagulyan; Jakob Neef; Lina María Jaime Tobón
Published in: EMBO Journal, 2023, ISSN 0261-4189
Publisher: EMBO press
DOI: 10.15252/EMBJ.2023114587

Other (2)

SynapseNet: Deep Learning for Automatic Synapse Reconstruction

Author(s): Sarah Muth, Frederieke Moschref, Luca Freckmann, Sophia Mutschall, Ines Hojas-Garcia-Plaza, Julius N. Bahr, Arsen Petrovic, Thanh Thao Do, Valentin Schwarze, Anwai Archit, Kirsten Weyand, Susann Michanski, Lydia Maus, Cordelia Imig, Nils Brose, Carolin Wichmann, Ruben Fernandez-Busnadiego, Tobias Moser, Silvio O. Rizzoli, Benjamin H. Cooper, Constantin Pape
Published in: 2024
Publisher: Cold Spring Harbor Laboratory
DOI: 10.1101/2024.12.02.626387

Gating of hair cell Ca²⁺channels governs the activity of cochlear neurons

Author(s): Nare Karagulyan, Anupriya Thirumalai, Susann Michanski, Yumeng Qi, Qinghua Fang, Haoyu Wang, Nadine J. Ortner, Jörg Striessnig, Nicola Strenzke, Carolin Wichmann, Yunfeng Hua, Tobias Moser
Published in: 2025
Publisher: Cold Spring Harbor Laboratory
DOI: 10.1101/2025.01.23.634330