Deciphering cellular and molecular mechanisms of β-cell regeneration

Project Information

BetaRegeneration

Grant agreement ID: 101054564

DOI

10.3030/101054564

EC signature date 26 July 2022

Start date 1 November 2022

End date 31 October 2027

Funded under

• European Research Council (ERC)

Total cost

€ 2 446 645,00

EU contribution

€ 2 446 645,00

Coordinated by

HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH
Germany

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Deliverables

Data Management Plan (1)

Data Management Plan

Publications

Peer reviewed articles (3)

Global, neuronal or β cell-specific deletion of inceptor improves glucose homeostasis in male mice with diet-induced obesity

Author(s): Gerald Grandl, Gustav Collden, Jin Feng, Sreya Bhattacharya, Felix Klingelhuber, Leopold Schomann, Sara Bilekova, null Ansarullah, Weiwei Xu, Fataneh Fathi Far, Monica Tost, Tim Gruber, Aimée Bastidas-Ponce, Qian Zhang, Aaron Novikoff, Arkadiusz Liskiewicz, Daniela Liskiewicz, Cristina Garcia-Caceres, Annette Feuchtinger, Matthias H. Tschöp, Natalie Krahmer, Heiko Lickert, Timo D. Müller
Published in: Nature Metabolism, 2024, ISSN 2522-5812
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/s42255-024-00991-3

Delineating mouse β-cell identity during lifetime and in diabetes with a single cell atlas

Author(s): Karin Hrovatin, Aimée Bastidas-Ponce, Mostafa Bakhti, Luke Zappia, Maren Büttner, Ciro Salinno, Michael Sterr, Anika Böttcher, Adriana Migliorini, Heiko Lickert, Fabian J. Theis
Published in: Nature Metabolism, Issue 5, 2023, ISSN 2522-5812
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/s42255-023-00876-x

Inceptor binds to and directs insulin towards lysosomal degradation in β cells

Author(s): Johanna Siehler, Sara Bilekova, Prisca Chapouton, Alessandro Dema, Pascal Albanese, Sem Tamara, Chirag Jain, Michael Sterr, Stephen J. Enos, Chunguang Chen, Chetna Malhotra, Adrian Villalba, Leopold Schomann, Sreya Bhattacharya, Jin Feng, Melis Akgün Canan, Federico Ribaudo, null Ansarullah, Ingo Burtscher, Christin Ahlbrecht, Oliver Plettenburg, Thomas Kurth, Raphael Scharfmann, Stephan Speier, Richard A. Scheltema, Heiko Lickert
Published in: Nature Metabolism, 2024, ISSN 2522-5812
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/s42255-024-01164-y