Unraveling the regulatory networks in Streptomyces that switch on antibiotic production on demand

Project Information

COMMUNITY

Grant agreement ID: 101055020

DOI

10.3030/101055020

EC signature date 30 May 2022

Start date 1 September 2022

End date 31 August 2027

Funded under

• European Research Council (ERC)

Total cost

€ 3 343 206,00

EU contribution

€ 3 343 206,00

Coordinated by

UNIVERSITEIT LEIDEN
Netherlands

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (6)

Harnessing regulatory networks in Actinobacteria for natural product discovery

Author(s): Hannah E Augustijn; Anna M Roseboom; Marnix H Medema; Gilles P van Wezel
Published in: JIMB, 2024, ISSN 1476-5535
Publisher: Oxford Academic
DOI: 10.1093/jimb/kuae011

LogoMotif: A Comprehensive Database of Transcription Factor Binding Site Profiles in Actinobacteria

Author(s): Hannah E. Augustijn, Dimitris Karapliafis, Kristy M.M. Joosten, Sébastien Rigali, Gilles P. van Wezel, Marnix H. Medema
Published in: Journal of Molecular Biology, Issue 436, 2024, ISSN 0022-2836
Publisher: Elsevier BV
DOI: 10.1016/j.jmb.2024.168558

Systems-wide analysis of the ROK-family regulatory gene <i>rokL6</i> and its role in the control of glucosamine toxicity in <i>Streptomyces coelicolor</i>

Author(s): Chao Li, Mia Urem, Chao Du, Le Zhang, Gilles P. van Wezel
Published in: Applied and Environmental Microbiology, Issue 89, 2023, ISSN 0099-2240
Publisher: American Society for Microbiology
DOI: 10.1128/aem.01674-23

CUBIC: A Versatile Cumate-Based Inducible CRISPRi System in Streptomyces.

Author(s): Bai C, van Wezel GP
Published in: ACS Synthetic Biology, 2023, ISSN 2161-5063
Publisher: American Chemical Society
DOI: 10.1021/acssynbio.3c00464.

Taxonomic and metabolic diversity of <scp>Actinomycetota</scp> isolated from faeces of a 28,000‐year‐old mammoth

Author(s): Doris A. van Bergeijk, Hannah E. Augustijn, Somayah S. Elsayed, Joost Willemse, Victor J. Carrión, Chao Du, Mia Urem, Lena V. Grigoreva, Maksim Y. Cheprasov, Semyon Grigoriev, Hans Jansen, Bas Wintermans, Andries E. Budding, Herman P. Spaink, Marnix H. Medema, Gilles P. van Wezel
Published in: Environmental Microbiology, Issue 26, 2024, ISSN 1462-2912
Publisher: Wiley
DOI: 10.1111/1462-2920.16589

A BioBricks Metabolic Engineering Platform for the Biosynthesis of Anthracyclinones in <i>Streptomyces coelicolor</i>

Author(s): Rongbin Wang, Jennifer Nguyen, Jacob Hecht, Nora Schwartz, Katelyn V. Brown, Larissa V. Ponomareva, Magdalena Niemczura, Dino van Dissel, Gilles P. van Wezel, Jon S. Thorson, Mikko Metsä-Ketelä, Khaled A. Shaaban, S. Eric Nybo
Published in: ACS Synthetic Biology, Issue 11, 2023, ISSN 2161-5063
Publisher: American Chemical Society (ACS)
DOI: 10.1021/acssynbio.2c00498