Project description
3D growth strategies in multicellular organisms
For most animals and land plants, tri-dimensional (3D) growth occurs in embryogenesis. In other multicellular organisms, it comes later. These large phylogenetic distances between current model organisms complicate the investigation of the mechanisms related to 3D growth strategies diversity. However, brown algae present all these 3D growth modes in a single clade. Additionally, their independent and recent evolution suggests the development of divergent 3D growth mechanisms. The EU-funded ALTER e-GROW project will identify the mechanisms of 3D tissue development in multicellular organisms. The project will observe and measure 3D growth parameters in four brown algae species, each representative of the 3D growth mechanisms found in animals, plants and fungi.
Objective
ALTER e-GROW aims to identify the mechanisms underlying the development of tri-dimensional (3D) tissues in multicellular organisms. Many physical factors influence the shape of an organism growing from a single cell or a small group of cells: the direction of growth along the x, y and z axis; when and how rapidly growth occurs, and whether the region of growth is diffuse or localised. An almost infinite number of combinations of these factors are possible. Most animals and land plants grow in 3D from the onset of embryogenesis. Other multicellular organisms, however, grow in 3D later in their development; for example, by emergence of a 3D bud from a single row of cells (as in mosses) or by aggregation of hyphae (as in fungi). The large phylogenetic distances between current model organisms complicate the investigation of the mechanisms underlying this diversity of 3D growth strategies. Brown algae, by contrast, display all of these 3D growth modes in a single clade, making them a unique subject for investigation of the mechanisms. Moreover, their independent and recent evolution when compared to the other clades suggests that they have developed divergent 3D growth mechanisms. In this project, my team will observe and quantify parameters of 3D growth in four species of brown algae, each representative of one of the main types of 3D growth mechanisms also found in animals, plants and Fungi. Then we will build dynamic mathematical models that describe these mechanisms by integrating quantitative data on cell shape, cell wall thickness and stiffness, cytoskeleton organisation, turgor and cellcell tension in dynamic 3D growth simulations, and test them by comparing the 3D growth pattern of wild type algae and genetic mutants. Thus, this project will pioneer what is currently a black box of knowledge about the development of brown algae, examining how these organisms raise multicellular structures in 3D space.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences microbiology phycology
- natural sciences biological sciences microbiology mycology
- natural sciences biological sciences developmental biology
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.1 - European Research Council (ERC)
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
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Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-ERC - HORIZON ERC Grants
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Call for proposal
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) ERC-2021-ADG
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75794 PARIS
France
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