Endothelial immunosuppressive mystery genes for alternative immunotherapy: artificial intelligence-driven target discovery and lipid nanoparticle/RNA-based target validation

Project Information

MystIMEC

Grant agreement ID: 101055155

DOI

10.3030/101055155

EC signature date 19 October 2022

Start date 1 March 2023

End date 29 February 2028

Funded under

• European Research Council (ERC)

Total cost

€ 3 498 426,00

EU contribution

€ 3 498 426,00

Coordinated by

VIB VZW
Belgium

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Data Management Plan (1)

Data Management Plan

Drafting of data management plan

Publications

Peer reviewed articles (11)

Nature Communications

Author(s): Liliana Sokol, Anne Cuypers, Anh-Co K Truong, Ann Bouché, Katleen Brepoels, Joris Souffreau, Katerina Rohlenova, Stefan Vinckier, Luc Schoonjans, Guy Eelen, Mieke Dewerchin, Laura P M H de Rooij, Peter Carmeliet
Published in: Communications Biology, 2023, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/S42003-023-05006-7

Detailed protocol for a corneal thermal cauterization-based (lymph-)angiogenesis assay in mice

Author(s): Anh-Co K. Truong; Lisa M. Becker; Nora Dekoning; Ann Bouché; Koen Veys; Baharak Hosseinkhani; Mieke Dewerchin; Guy Eelen; Peter Carmeliet
Published in: MethodsX, 2023, ISSN 2215-0161
Publisher: Elsevier
DOI: 10.1016/J.MEX.2023.102446

Endothelial dysfunction in the aging kidney

Author(s): M Borri; ME Jacobs; P Carmeliet; TJ Rabelink; SJ Dumas
Published in: American Journal of Physiology-Renal Physiology, 2025, ISSN 1522-1466
Publisher: American Physiological Society
DOI: 10.1152/AJPRENAL.00287.2024

Deciphering endothelial heterogeneity in health and disease at single-cell resolution: progress and perspectives

Author(s): Lisa M Becker, Shiau-Haln Chen, Julie Rodor, Laura P M H de Rooij, Andrew H Baker, Peter Carmeliet
Published in: Cardiovascular Research, 2022, ISSN 1755-3245
Publisher: Oxford University Press
DOI: 10.1093/CVR/CVAC018

Nature Reviews Clinical Oncology

Author(s): Sophia Daum; Lilith Decristoforo; Mira Mousa; Stefan Salcher; Christina Plattner; Baharak Hosseinkhani; Zlatko Trajanoski; Dominik Wolf; Peter Carmeliet; Andreas Pircher
Published in: Molecular Cancer, 2025, ISSN 1759-4774
Publisher: Nature Publishing Group
DOI: 10.1186/S12943-024-02221-6

Understanding tumour endothelial cell heterogeneity and function from single-cell omics

Author(s): Qun Zeng, Mira Mousa, Aisha Shigna Nadukkandy, Lies Franssens, Halima Alnaqbi, Fatima Yousif Alshamsi, Habiba Al Safar, Peter Carmeliet
Published in: Nature Reviews Cancer, 2023, ISSN 2058-8437
Publisher: Springer Nature
DOI: 10.1038/S41568-023-00591-5

Unveiling the immunomodulatory dance: endothelial cells’ function and their role in non-small cell lung cancer

Author(s): Sophia Daum, Lilith Decristoforo, Mira Mousa, Stefan Salcher, Christina Plattner, Baharak Hosseinkhani, Zlatko Trajanoski, Dominik Wolf, Peter Carmeliet, Andreas Pircher
Published in: Molecular Cancer, Issue 24, 2025, ISSN 1476-4598
Publisher: Springer Science and Business Media LLC
DOI: 10.1186/S12943-024-02221-6

Cell Reports

Author(s): Christine Germeys, Tijs Vandoorne, Kristofer Davie, Suresh Poovathingal, Kara Heeren, Wendy Vermeire, FatemehArefeh Nami, Matthieu Moisse, Annelies Quaegebeur, Annerieke Sierksma, Laura Rué, Adrià Sicart, Caroline Eykens, Lenja De Cock, Bart De Strooper,
Published in: Cell Reports, 2024, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/J.CELREP.2024.114719

A single endothelial cell mega-atlas across human tissues in health and disease

Author(s): Koen Veys, et al.
Published in: Cell Reports, 2025, ISSN 2211-1247
Publisher: Elsevier
DOI: 10.1038/s41591-023-02327-2

Immunomodulation by endothelial cells: prospects for cancer therapy

Author(s): Halima Alnaqbi, Lisa M Becker, Mira Mousa, Fatima Alshamsi, Sarah K Azzam, Besa Emini Veseli, Lauren A Hymel, Khalood Alhosani, Marwa Alhusain, Massimiliano Mazzone , Habiba Alsafar, Peter Carmeliet
Published in: Trends in Cancer, 2024, ISSN 2405-8025
Publisher: Elsevier
DOI: 10.1016/J.TRECAN.2024.08.002

Single-cell RNA sequencing of cystic fibrosis liver disease explants reveals endothelial complement activation

Author(s): Mathias Declercq, Lucas Treps, Vincent Geldhof, Nadine V Conchinha, Laura P M H de Rooij, Abhishek Subramanian, Magalie Feyeux, Marine Cotinat, Bram Boeckx, Stefan Vinckier, Lieven Dupont, Francois Vermeulen, Mieke Boon, Marijke Proesmans, Louis Libbrecht
Published in: Liver International, 2024, ISSN 1478-3231
Publisher: John Wiley & Sons.
DOI: 10.1111/LIV.15963