Developing novel single-cell technologies to model and perturb intra-tumor interactions and signaling – an innovation program for the next generation of immunotherapies

Project Information

TROJAN-Cell

Grant agreement ID: 101055341

DOI

10.3030/101055341

EC signature date 27 June 2022

Start date 1 October 2022

End date 30 September 2027

Funded under

• European Research Council (ERC)

Total cost

€ 2 500 000,00

EU contribution

€ 2 500 000,00

Coordinated by

WEIZMANN INSTITUTE OF SCIENCE
Israel

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (4)

Spatial and Temporal Mapping of Breast Cancer Lung Metastases Identify TREM2 Macrophages as Regulators of the Metastatic Boundary

Author(s): Ido Yofe, Tamar Shami, Noam Cohen, Tomer Landsberger, Fadi Sheban, Liat Stoler-Barak, Adam Yalin, Truong San Phan, Baoguo Li, Lea Monteran, Ye'ela Scharff, Amir Giladi, Miriam Elbaz, Eyal David, Anna Gurevich-Shapiro, Chamutal Gur, Ziv Shulman, Neta Erez, Ido Amit
Published in: Cancer Discovery, Issue 13, 2023, ISSN 2159-8274
Publisher: American Association for Cancer Research (AACR)
DOI: 10.1158/2159-8290.CD-23-0299

Modeling T cell temporal response to cancer immunotherapy rationalizes development of combinatorial treatment protocols

Author(s): Oren Barboy, Akhiad Bercovich, Hanjie Li, Yaniv Eyal-Lubling, Adam Yalin, Yuval Shapir Itai, Kathleen Abadie, Mor Zada, Eyal David, Shir Shlomi-Loubaton, Yonatan Katzenelenbogen, Diego Adhemar Jaitin, Chamutal Gur, Ido Yofe, Tali Feferman, Merav Cohen, Rony Dahan, Evan W. Newell, Aviezer Lifshitz, Amos Tanay, Ido Amit
Published in: Nature Cancer, Issue 5, 2024, ISSN 2662-1347
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/s43018-024-00734-z

Time-resolved single-cell transcriptomics defines immune trajectories in glioblastoma

Author(s): Daniel Kirschenbaum, Ken Xie, Florian Ingelfinger, Yonatan Katzenelenbogen, Kathleen Abadie, Thomas Look, Fadi Sheban, Truong San Phan, Baoguo Li, Pascale Zwicky, Ido Yofe, Eyal David, Kfir Mazuz, Jinchao Hou, Yun Chen, Hila Shaim, Mayra Shanley, Soeren Becker, Jiawen Qian, Marco Colonna, Florent Ginhoux, Katayoun Rezvani, Fabian J. Theis, Nir Yosef, Tobias Weiss, Assaf Weiner, Ido Amit
Published in: Cell, Issue 187, 2024, ISSN 0092-8674
Publisher: Elsevier BV
DOI: 10.1016/j.cell.2023.11.032

Bispecific dendritic-T cell engager potentiates anti-tumor immunity

Author(s): Shapir Itai Y, Barboy O, Salomon R, Bercovich A, Xie K, Winter E, Shami T, Porat z, Erez N, Tanay A, Amit I, Dahan R
Published in: CELL, Issue 187(2):375-389.e18., 2024, ISSN 1097-4172
Publisher: cell
DOI: 10.1016/j.cell.2023.12.011