EXPANDing Immune Cells and their Tumor Antigens during checkpoint immunotherapy

Project Information

EXPAND IT

Grant agreement ID: 101055422

DOI

10.3030/101055422

EC signature date 29 September 2022

Start date 1 January 2023

End date 31 December 2027

Funded under

• European Research Council (ERC)

Total cost

€ 2 500 000,00

EU contribution

€ 2 500 000,00

Coordinated by

VIB VZW
Belgium

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (8)

CD4+ T cell activation distinguishes response to anti-PD-L1+anti-CTLA4 therapy from anti-PD-L1 monotherapy

Author(s): Amelie Franken, Michel Bila, Aurelie Mechels, Sam Kint, Jeroen Van Dessel, Valentina Pomella, Sebastiaan Vanuytven, Gino Philips, Orian Bricard, Jieyi Xiong, Bram Boeckx, Sigrid Hatse, Thomas Van Brussel, Rogier Schepers, Cedric Van Aerde, Sarah Geurs, Vincent Vandecaveye, Esther Hauben, Vincent Vander Poorten, Sara Verbandt, Katy Vandereyken, Junbin Qian, Sabine Tejpar, Thierry Voet, Paul M. Clement, Diether Lambrechts
Published in: Immunity, Issue 57, 2024, ISSN 1074-7613
Publisher: Elsevier BV
DOI: 10.1016/J.IMMUNI.2024.02.007

Rapid autopsies to enhance metastatic research: the UPTIDER post-mortem tissue donation program

Author(s): Tatjana Geukens; Maxim De Schepper; Wouter Van Den Bogaert; Karen Van Baelen; Marion Maetens; Anirudh Pabba; Amena Mahdami; Sophia Leduc; Edoardo Isnaldi; Ha-Linh Nguyen; Imane Bachir; Maysam Hajipirloo; Gitte Zels; Josephine Van Cauwenberge; Kristien Borremans; Vincent Vandecaveye; Birgit Weynand; Peter Vermeulen; Eleonora Leucci; Maria Francesca Baietti; George Sflomos; Laura Battista; Cathrin Brisken; Patrick W. B. Derksen; Thijs Koorman; Daan Visser; Colinda L. G. J. Scheele; Daniela S. Thommen; Sigrid Hatse; Sarah-Maria Fendt; Evy Vanderheyden; Thomas Van Brussel; Rogier Schepers; Bram Boeckx; Diether Lambrechts; Giuseppe Marano; Elia Biganzoli; Ann Smeets; Ines Nevelsteen; Kevin Punie; Patrick Neven; Hans Wildiers; François Richard; Giuseppe Floris; Christine Desmedt
Published in: npj Breast Cancer, Issue 10, 2024, ISSN 2374-4677
Publisher: NATURE PORTFOLIO
DOI: 10.1038/S41523-024-00637-3

Single-cell RNA seq-derived signatures define response patterns to atezolizumab + bevacizumab in advanced hepatocellular carcinoma

Author(s): Sarah Cappuyns, Marta Piqué-Gili, Roger Esteban-Fabró, Gino Philips, Ugne Balaseviciute, Roser Pinyol, Albert Gris-Oliver, Vincent Vandecaveye, Jordi Abril-Fornaguera, Carla Montironi, Laia Bassaganyas, Judit Peix, Marcus Zeitlhoefler, Agavni Mesropian, Júlia Huguet-Pradell, Philipp K. Haber, Igor Figueiredo, Giorgio Ioannou, Edgar Gonzalez-Kozlova, Antonio D’Alessio, Raphael Mohr, Tim Meyer, Anja Lachenmayer, Jens U. Marquardt, Helen L. Reeves, Julien Edeline, Fabian Finkelmeier, Jörg Trojan, Peter R. Galle, Friedrich Foerster, Beatriz Mínguez, Robert Montal, Sacha Gnjatic, David J. Pinato, Mathias Heikenwalder, Chris Verslype, Eric Van Cutsem, Diether Lambrechts, Augusto Villanueva, Jeroen Dekervel, Josep M. Llovet
Published in: Journal of Hepatology, 2024, ISSN 0168-8278
Publisher: Elsevier BV
DOI: 10.1016/J.JHEP.2024.12.016

Continuous replenishment of the dysfunctional CD8 T cell axis is associated with response to chemoimmunotherapy in advanced breast cancer

Author(s): Christina Metoikidou, Vadim Karnaukhov, Bram Boeckx, Eleonora Timperi, Pierre-Emmanuel Bonté, Ling Wang, Marion Espenel, Benoit Albaud, Delphine Loirat, Xiaoxiao Wang, Christos Sotiriou, Philippe Aftimos, Kevin Punie, Hans Wildiers, Viktorija Labroska, Ming-Wei Wang, Joshua J. Waterfall, Martine Piccart-Gebhart, Thierry Mora, Aleksandra Walczak, Olivier Lantz, Laurence Buisseret, Diether Lambrechts, Sebastian Amigorena, Emanuela Romano
Published in: Cell Reports Medicine, 2025, ISSN 2666-3791
Publisher: Elsevier BV
DOI: 10.1016/J.XCRM.2025.101973

Nature Communications

Author(s): Sarah Cappuyns; Gino Philips; Vincent Vandecaveye; Bram Boeckx; Rogier Schepers; Thomas Van Brussel; Ingrid Arijs; Aurelie Mechels; Ayse Bassez; Francesca Lodi; Joris Jaekers; Halit Topal; Baki Topal; Orian Bricard; Junbin Qian; Eric Van Cutsem; Chris Verslype; Diether Lambrechts; Jeroen Dekervel
Published in: Nature Communications, Issue 14, 2023, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-023-43381-1

TKI resistance in brain metastasis: A CTLA4 state of mind

Author(s): Elena Donders, Diether Lambrechts
Published in: Immunity, Issue 57, 2024, ISSN 1074-7613
Publisher: CELL PRESS
DOI: 10.1016/j.immuni.2024.10.009

Single-cell Atlas of Penile Cancer Reveals TP53 Mutations as a Driver of an Aggressive Phenotype, Irrespective of Human Papillomavirus Status, and Provides Clues for Treatment Personalization

Author(s): Laura Elst, Gino Philips, Kaat Vandermaesen, Ayse Bassez, Francesca Lodi, Manon T.A. Vreeburg, Oscar R. Brouwer, Rogier Schepers, Thomas Van Brussel, Sambit K. Mohanty, Anil V. Parwani, Lien Spans, Isabelle Vanden Bempt, Gerd Jacomen, Marcella Baldewijns, Diether Lambrechts, Maarten Albersen
Published in: European Urology, Issue 86, 2024, ISSN 0302-2838
Publisher: Elsevier BV
DOI: 10.1016/j.eururo.2024.03.038

Protocol for whole-slide image analysis of human multiplexed tumor tissues using QuPath and R

Author(s): Amelie Franken, Michel Bila, Diether Lambrechts
Published in: STAR Protocols, Issue 5, 2024, ISSN 2666-1667
Publisher: Elsevier BV
DOI: 10.1016/j.xpro.2024.103270