Implementing a patient-centred and evidence-based intervention to reduce BEnzodiazepine and sedative-hypnotic use to improve patient SAFEty and quality of care

Project Information

BE-SAFE

Grant agreement ID: 101057123

DOI

10.3030/101057123

EC signature date 18 May 2022

Start date 1 September 2022

End date 31 August 2027

Funded under

• Health

Total cost

€ 4 883 232,00

EU contribution

€ 4 883 229,00

Coordinated by

UNIVERSITE CATHOLIQUE DE LOUVAIN
Belgium

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Websites, patent fillings, videos etc. (1)

Public website

Public website up and running to centralise BE-SAFE products

Documents, reports (3)

Clinical pathways and healthcare systems

Current key clinical pathways (or care trajectories) in relation to BSH reduction identified and described in the six participating European countries

Guidelines to reduce BSHs

Trustworthy guidelines to reduce BSHs published on MAGICapp website and BE-SAFE portal

Barriers and enablers to reduce BSHs

Report of the survey, presenting the barriers and enablers to discontinuing BSHs among patients, informal carers and health care professionals in the six European countries

Publications

Peer reviewed articles (7)

Steel in Translation

Author(s): Vladyslav Shapoval; Andrea M. Patey; Séverine Henrard; Anne Spinewine
Published in: Internal and Emergency Medicine, 2024, ISSN 1970-9366
Publisher: Institute of Materials
DOI: 10.1007/S11739-024-03675-8

Comparative effectiveness of interventions to facilitate deprescription of benzodiazepines and other sedative hypnotics: systematic review and meta-analysis

Author(s): Dena Zeraatkar, Sumanth Kumbargere Nagraj, Michael Ling, Tanvir Jassal, Sarah Kirsh, João Pedro Lima, Tyler Pitre, Rachel Couban, Muizz Hussain, Siri Seterelv, Stijn Van de Velde, Katarzyna Gustavsson, Adam Wichniak, Carole E Aubert, Antoine Christiaens, Anne Spinewine, Thomas Agoritsas
Published in: BMJ, Issue 389, 2025, ISSN 1756-1833
Publisher: BMJ
DOI: 10.1136/BMJ-2024-081336

Comparative effectiveness of interventions to facilitate deprescription of benzodiazepines and other sedative hypnotics: systematic review and meta-analysis

Author(s): Dena Zeraatkar, Sumanth Kumbargere Nagraj, Michael Ling, Tanvir Jassal, Sarah Kirsh, João Pedro Lima, Tyler Pitre, Rachel Couban, Muizz Hussain, Siri Seterelv, Stijn Van de Velde, Katarzyna Gustavsson, Adam Wichniak, Carole E Aubert, Antoine Christiaens, Anne Spinewine, Thomas Agoritsas
Published in: BMJ, Issue 389, 2025, ISSN 1756-1833
Publisher: BMJ
DOI: 10.1136/BMJ-2024-081336

Equipping physicians for benzodiazepine receptor agonists deprescription in older adults: theory-based development of the BE-SAFE intervention

Author(s): François-Xavier Sibille, Joanna Salbert, Lucy Bolt, Vagioula Tsoutsi, Enrico Callegari, Olivia Dalleur, Tokandji Adda, Thomas Agoritsas, Thomas Berger, Carole E. Aubert, Dimitris Dikeos, Antoni Salvà, Begoña Pascual, Ramon Miralles, Torgeir Bruun Wyller, Andrea M. Patey, Jeremy M. Grimshaw, Adam Wichniak, Anne Spinewine, Marie de Saint Hubert
Published in: Research in Social and Administrative Pharmacy, Issue 21, 2025, ISSN 1551-7411
Publisher: Elsevier BV
DOI: 10.1016/J.SAPHARM.2025.05.002

Barriers to Deprescribing Benzodiazepines in Older Adults in a Survey of European Physicians

Author(s): Vladyslav Shapoval, Marie de Saint Hubert, Perrine Evrard, François-Xavier Sibille, Carole E. Aubert, Lucy Bolt, Vagioula Tsoutsi, Pinelopi Kollia, Antoni Salvà, Ramon Miralles, Adam Wichniak, Katarzyna Gustavsson, Torgeir Bruun Wyller, Enrico Callegari, Jeremy M. Grimshaw, Justin Presseau, Séverine Henrard, Anne Spinewine
Published in: JAMA Network Open, Issue 8, 2025, ISSN 2574-3805
Publisher: American Medical Association (AMA)
DOI: 10.1001/JAMANETWORKOPEN.2024.59883

Deprescribing benzodiazepine receptor agonists for insomnia in older adults

Author(s): Antoine Christiaens, Carole E Aubert, Adam Wichniak, Antoni Salvà Casanovas, Anne Spinewine
Published in: The Lancet, Issue 402, 2023, ISSN 0140-6736
Publisher: Elsevier BV
DOI: 10.1016/S0140-6736(23)01562-3

Barriers to and Enablers of Supporting Deprescribing Benzodiazepines in Older Adults: A Survey of European Nonphysician Healthcare Professionals

Author(s): Vladyslav Shapoval, Perrine Evrard, François‐Xavier Sibille, María López‐Toribio, Olivia Dalleur, Carole E. Aubert, Lucy Bolt, Vagioula Tsoutsi, Maria Ntafouli, Laura Fernández Maldonado, Ramon Miralles, Adam Wichniak, Katarzyna Gustavsson, Torgeir Bruun Wyller, Enrico Callegari, Jeremy M. Grimshaw, Justin Presseau, Séverine Henrard, Anne Spinewine
Published in: Basic & Clinical Pharmacology & Toxicology, Issue 137, 2025, ISSN 1742-7835
Publisher: Wiley
DOI: 10.1111/BCPT.70100

Other (3)

Guideline - BE-SAFE: Deprescription of benzodiazepine and sedative hypnotics (BSHs) in insomnia disorder

Author(s): Thomas Agoritsas; Sumanth Kumbargere Nagraj; Enrico Callegari; Minna Johansson
Published in: 2023
Publisher: MAGIC Evidence Ecosystem Foundation

BE-SAFE: Deprescription of benzodiazepine and sedative hypnotics (BSHs) in insomnia disorder

Author(s): Thomas Agoritsas; Sumanth Kumbargere Nagraj; Enrico Callegari; Minna Johansson
Published in: 2023
Publisher: MAGIC Evidence Ecosystem Foundation
DOI: 10.1111/den.14531

Deprescribing benzodiazepine receptor agonists for insomnia in older adults

Author(s): Antoine Christiaens; Carole E Aubert; Adam Wichniak; Antoni Salvà Casanovas; Anne Spinewine
Published in: The Lancet, 2023
Publisher: The Lancet
DOI: 10.1016/S0140-6736(23)01562-3