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Mapping the Evidence for the WHO Classification of Tumours: a Living Evidence Gap Map by Tumour Type.

Objective

The WHO Classification of Tumours (WCT) underpins cancer diagnosis, and hence treatment and care of cancer patients, as well as research into cancer epidemiology, prevention, diagnosis, and treatment. However, decisions for such a global reference tool are not always informed by the best available evidence, and risks of incorporating misinformation into the clinical decisions pathway exist. We aim to develop a tool that maps existing evidence, showing gaps, identifying pockets of low-level evidence, and synthesis of reliable evidence. The tool will map the evidence base of the WCT in order to facilitate evidence-based decision-making in pathology, and promote the application of higher research standards in the field. We will adapt the recently developed Evidence Gap Map (EGM) methodology, first time ever to be used in biomedicine. The resulting EGMs will increase the discoverability and use of studies by the WCT decision-makers, research commissioners, researchers and others. Our WCT-EVI-MAP project is organized in three subsequent phases, where we will apply a stepwise approach to: first, develop a framework and define evidence levels based on expert consensus; second, elaborate a series of Megamaps in iterative cycles describing evidence of all tumour types; third, perform a descriptive analysis of the use of evidence in a continuous updated exercise. To overcome identified challenges, several strategies are proposed, such as using recent advances in technologies, following a strict multidisciplinary approach and integrating this project into the WCT strategic planning for the 6th edition. We believe that the WCT EVI-MAP will represent a ground-breaking advance for the WCT and research in the field, and will accelerate progress in cancer diagnosis and management. Integration of evidence-based medicine methods has been shown to have a positive impact in other specialized medical fields and our project represents a first step towards an evidence-based pathology.

Coordinator

CENTRE INTERNATIONAL DE RECHERCHE SUR LE CANCER
Net EU contribution
€ 844 712,00
Address
150 Cours Albert Thomas
69372 Lyon Cedex 08
France

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Region
Auvergne-Rhône-Alpes Rhône-Alpes Rhône
Activity type
Research Organisations
Non-EU contribution
€ 0,50

Participants (3)

INSTITUTO DE SALUD CARLOS III
Spain
Net EU contribution
€ 654 375,00
Address
Monforte De Lemos 5
28029 Madrid

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Region
Comunidad de Madrid Comunidad de Madrid Madrid
Activity type
Research Organisations
Non-EU contribution
€ 0,00
Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - Panstwowy Instytut Badawczy
Poland
Net EU contribution
€ 619 341,00
Address
Ul. W K Roentgena 5
02781 Warszawa

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Region
Makroregion województwo mazowieckie Warszawski stołeczny Miasto Warszawa
Activity type
Research Organisations
Non-EU contribution
€ 0,25
DEUTSCHES HERZZENTRUM MUNCHEN
Germany
Net EU contribution
€ 649 812,00
Address
Lazarettstrasse 36
80636 Munich

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Region
Bayern Oberbayern München, Kreisfreie Stadt
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Non-EU contribution
€ 0,50