Project description
Innovative combined therapy for osteoarthritis management
Osteoarthritis (OA) is a degenerative disease affecting any joint across the body and afflicting millions of people. Current interventions include analgesic, anti-inflammatory drugs and intra-articular injections of steroids and hyaluronic acid (IA-HA), with moderate efficacy. The EU-funded SINPAIN project aims to understand OA to develop a pipeline of therapies based on small interfering RNA (siRNA) for the management of knee OA and an AI tool to help clinicians in diagnostic and treatment choice. As part of it, a nanoformulation of functional IA-HA loaded with siRNA vectors targeting inflammation and pain pathways will be developed. To validate the efficacy of the identified targets, 3D culture human cell models will be developed for testing in bioreactors mimicking the joint’s environment and biomechanics.
Fields of science
- engineering and technologyenvironmental biotechnologybioremediationbioreactors
- medical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugs
- medical and health sciencesbasic medicineimmunology
- medical and health sciencesmedical biotechnologynanomedicine
- natural sciencescomputer and information sciencesartificial intelligencemachine learning
Programme(s)
Funding Scheme
RIA - Research and Innovation actionCoordinator
20014 San Sebastian
Spain
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Participants (9)
13288 Marseille
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
66123 Saarbrucken
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08014 Barcelona
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
4200-135 Porto
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13100 Vercelli
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66386 St Ingbert
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
102 Reykjavik
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94607 Oakland Ca
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75654 Paris
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Partners (2)
7270 Davos Platz
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L69 7ZX Liverpool
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