Skip to main content

A game changer for the treatment of osteoarthritis: a cost effective combined advanced therapy to treat knee osteoarthritis

Project description

Innovative combined therapy for osteoarthritis management

Osteoarthritis (OA) is a degenerative disease affecting any joint across the body and afflicting millions of people. Current interventions include analgesic, anti-inflammatory drugs and intra-articular injections of steroids and hyaluronic acid (IA-HA), with moderate efficacy. The EU-funded SINPAIN project aims to understand OA to develop a pipeline of therapies based on small interfering RNA (siRNA) for the management of knee OA and an AI tool to help clinicians in diagnostic and treatment choice. As part of it, a nanoformulation of functional IA-HA loaded with siRNA vectors targeting inflammation and pain pathways will be developed. To validate the efficacy of the identified targets, 3D culture human cell models will be developed for testing in bioreactors mimicking the joint’s environment and biomechanics.

Coordinator

FUNDACION CIDETEC
Net EU contribution
€ 1 286 250,00
Address
Paseo Miramon 196 Parque Tecnologico De Miramon
20014 San Sebastian
Spain

See on map

Region
Noreste País Vasco Gipuzkoa
Activity type
Research Organisations
Other funding
€ 0,00

Participants (9)

OZ BIOSCIENCES SAS
France
Net EU contribution
€ 509 605,00
Address
Parc Scientifique Et Technologique De Luminy Case 922 Bat Ccimp
13288 Marseille

See on map

SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Provence-Alpes-Côte d’Azur Provence-Alpes-Côte d’Azur Bouches-du-Rhône
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 0,00
UNIVERSITAT DES SAARLANDES
Germany
Net EU contribution
€ 714 750,00
Address
Campus
66123 Saarbrucken

See on map

Region
Saarland Saarland Regionalverband Saarbrücken
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00
ASPHALION SL
Spain
Net EU contribution
€ 204 375,00
Address
Calle Tarragona, Numeros 151-157, Planta 10, Bloqu
08014 Barcelona

See on map

SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Este Cataluña Barcelona
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 0,00
I3S - INSTITUTO DE INVESTIGACAO E INOVACAO EM SAUDE DA UNIVERSIDADE DO PORTO
Portugal
Net EU contribution
€ 515 515,00
Address
Rua Alfredo Allen 208
4200-135 Porto

See on map

Region
Continente Norte Área Metropolitana do Porto
Activity type
Research Organisations
Other funding
€ 0,00
UNIVERSITA DEGLI STUDI DEL PIEMONTE ORIENTALE AMEDEO AVOGADRO
Italy
Net EU contribution
€ 399 363,00
Address
Duomo 6
13100 Vercelli

See on map

Region
Nord-Ovest Piemonte Vercelli
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,75
EURICE EUROPEAN RESEARCH AND PROJECT OFFICE GMBH
Germany
Net EU contribution
€ 460 125,00
Address
Heinrich-hertz-allee 1
66386 St Ingbert

See on map

SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Saarland Saarland Saarpfalz-Kreis
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 0,00
HASKOLINN I REYKJAVIK EHF
Iceland
Net EU contribution
€ 462 500,00
Address
Menntavegur 1
102 Reykjavik

See on map

Region
Ísland Ísland Höfuðborgarsvæði
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
United States
Net EU contribution
€ 525 928,00
Address
Franklin Street 1111 12 Floor
94607 Oakland Ca

See on map

Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France
Net EU contribution
€ 309 146,00
Address
Rue De Tolbiac 101
75654 Paris

See on map

Region
Ile-de-France Ile-de-France Paris
Activity type
Research Organisations
Other funding
€ 0,25

Partners (2)

AO-FORSCHUNGSINSTITUT DAVOS
Switzerland
Net EU contribution
€ 0,00
Address
Clavadelerstrasse 8
7270 Davos Platz

See on map

Region
Schweiz/Suisse/Svizzera Ostschweiz Graubünden / Grigioni / Grischun
Activity type
Research Organisations
Other funding
€ 0,00
THE UNIVERSITY OF LIVERPOOL
United Kingdom
Net EU contribution
€ 0,00
Address
Brownlow Hill 765 Foundation Building
L69 7ZX Liverpool

See on map

Region
North West (England) Merseyside Liverpool
Activity type
Higher or Secondary Education Establishments
Other funding
No data