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Fully automated cell-free DNA extraction and quantification - liquid biopsies safely from Patient to Lab

Objective

Liquid biopsies are blood tests with growing potential in diagnostics for cancer and prenatal screening. Pre-analytical challenges, such as the need for skilled workforce and strict logistic requirements for samples transportation, are limiting the full exploitation of the method. To address these technical issues, we developed a method for immediate and automated sample processing that provides a sample with higher reliability, less human labour, and less transport requirements.

BiopSense innovation is a fully automated disposable cartridge, where the blood is filtrated using a dedicated hollow fiber membrane and then cfDNA is isolated from the plasma in the microfluidic system. The resulting sample can be then transported by regular post and eluted at the destination to carry out the final analysis. The cartridge is controlled by a control unit composed of a vacuum generator, software, and a simple spectrophotometer.

In this EIC Transition project our objectives are to validate the automated cfDNA extraction technology and to integrate all the features of the innovation in a single disposable cartridge, which will be ready for marketing, licensing and IVD validation by the end of the project. The cartridge design will be done in close collaboration with the potential customers sector (biotech companies and hospital laboratories) to use their feedback to develop the user interface, manufacturability, and regulatory compliance. The project will focus on the cartridge design and will outsource control unit development to a company with experience in vitro diagnostic devices designing and production.

In this project the commercialisation strategy for the next 5-10 years will be developed to define how our start-up company BiopSense will handle the disposable cartridge design and commercialization, and further R&D of the technology in additional applications.

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Keywords

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Programme(s)

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Topic(s)

Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.

Funding Scheme

Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.

HORIZON-EIC - HORIZON EIC Grants

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Call for proposal

Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.

(opens in new window) HORIZON-EIC-2021-TRANSITION-CHALLENGES-01

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Coordinator

BIOPSENSE OY
Net EU contribution

Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.

€ 2 500 000,00
Address
EERONKATU 10
40720 Jyvaskyla
Finland

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Links
Total cost

The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.

€ 2 500 000,00
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