automated in-line separatioN and dEtection of eXtracellular vesicles for liqUid biopsy applicationS

Project Information

NEXUS

Grant agreement ID: 101058200

DOI

10.3030/101058200

Project closed

EC signature date 19 May 2022

Start date 1 June 2022

End date 31 May 2025

Funded under

• The European Innovation Council (EIC)

Total cost

€ 2 497 750,00

EU contribution

€ 2 497 750,00

Coordinated by

CONSIGLIO NAZIONALE DELLE RICERCHE
Italy

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Documents, reports (2)

Dissemination and Communication Plan
Data Management Plan

Publications

Peer reviewed articles (10)

Dual-Domain Reporter Approach for Multiplex Identification of Major SARS-CoV-2 Variants of Concern in a Microarray-Based Assay

Author(s): Francesco Damin, Silvia Galbiati, Nicola Clementi, Roberto Ferrarese, Nicasio Mancini, Laura Sola, Marcella Chiari
Published in: Biosensors, Issue 13, 2023, ISSN 2079-6374
Publisher: MDPI AG
DOI: 10.3390/BIOS13020269

Stoichiometric constraints for detection of EV‐borne biomarkers in blood

Author(s): Nataša Zarovni, Danilo Mladenović, Dario Brambilla, Federica Panico, Marcella Chiari
Published in: Journal of Extracellular Vesicles, Issue 14, 2025, ISSN 2001-3078
Publisher: Wiley
DOI: 10.1002/JEV2.70034

Optimization of Functional Group Concentration of N, N-Dimethylacrylamide-based Polymeric Coatings and Probe Immobilization for DNA and Protein Microarray Applications

Author(s): L.Sola
Published in: Micromachines, 2023, ISSN 2072-666X
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/mi14020302

Optimization of Functional Group Concentration of N, N-Dimethylacrylamide-based Polymeric Coatings and Probe Immobilization for DNA and Protein Microarray Applications

Author(s): Laura Sola, Laura Abdel Mallak, Francesco Damin, Alessandro Mussida, Dario Brambilla, Marcella Chiari
Published in: Micromachines, Issue 14, 2023, ISSN 2072-666X
Publisher: MDPI AG
DOI: 10.3390/MI14020302

Biosensors

Author(s): F. Damin
Published in: Biosensors, 2023, ISSN 2079-6374
Publisher: MDPI
DOI: 10.3390/bios13020269

Immobilization of biotinylated antibodies through streptavidin binding aptamer

Author(s): D. Brambilla, L. Sola, F. Damin, A. Mussida, M. Chiari
Published in: Talanta, Issue 265, 2024, ISSN 0039-9140
Publisher: Elsevier BV
DOI: 10.1016/j.talanta.2023.124847

A label-free optical biosensor-based point-of-care test for the rapid detection of Monkeypox virus

Author(s): Mete Aslan, Elif Seymour, Howard Brickner, Alex E. Clark, Iris Celebi, Michael B. Townsend, Panayampalli S. Satheshkumar, Megan Riley, Aaron F. Carlin, M. Selim Ünlü, Partha Ray
Published in: Biosensors and Bioelectronics, Issue 269, 2024, ISSN 0956-5663
Publisher: Elsevier BV
DOI: 10.1016/J.BIOS.2024.116932

Copolymer-Coated Gold Nanoparticles: Enhanced Stability and Customizable Functionalization for Biological Assays

Author(s): Dario Brambilla, Federica Panico, Lorenzo Zarini, Alessandro Mussida, Anna M. Ferretti, Mete Aslan, M. Selim Ünlü, Marcella Chiari
Published in: Biosensors, Issue 14, 2024, ISSN 2079-6374
Publisher: MDPI AG
DOI: 10.3390/bios14070319

Roadblocks of Urinary EV Biomarkers: Moving Toward the Clinic

Author(s): Marvin Droste, Maija Puhka, Martin E. van Royen, Monica S. Y. Ng, Charles Blijdorp, Gloria Alvarez‐Llamas, Francesc E. Borràs, Anja K. Büscher, Benedetta Bussolati, James W. Dear, Juan M. Falcón‐Pérez, Bernd Giebel, Cristina Grange, Ewout J. Hoorn, Janne Leivo, Metka Lenassi, Alicia Llorente, Fabrice Lucien, Inge Mertens, Harald Mischak, Desmond Pink, Tobias Tertel, Swasti Tiwari, Dolores Di Vizio, Peter S. T. Yuen, Natasa Zarovni, Guido Jenster, Dylan Burger, Elena S. Martens‐Uzunova, Uta Erdbrügger
Published in: Journal of Extracellular Vesicles, Issue 14, 2025, ISSN 2001-3078
Publisher: Wiley
DOI: 10.1002/JEV2.70120

Separation of small extracellular vesicles (sEV) from human blood by Superose 6 size exclusion chromatography

Author(s): Jerome Nouvel, Gonzalo Bustos‐Quevedo, Tony Prinz, Ramsha Masood, George Daaboul, Tanja Gainey‐Schleicher, Uwe Wittel, Sophia Chikhladze, Bence Melykuti, Martin Helmstaedter, Karl Winkler, Irina Nazarenko, Gerhard Pütz
Published in: Journal of Extracellular Vesicles, Issue 13, 2024, ISSN 2001-3078
Publisher: Wiley
DOI: 10.1002/JEV2.70008

Other (3)

Pixel-diversity Interferometric Imaging: A New Paradigm in Digital Biosensing

Author(s): Selim Ünlü
Published in: 67th Biophysical Society Annual Meeting, 2023
Publisher: Biophysical Society

Coating of gold nanoparticles for enhanced stability and functionalization

Author(s): Zarini, L.; Brambilla, D.; Panico, F.; Mussida, A.; Ferretti, A.M.; Aslan, M.; Unlu, M.S.; Chiari, M.
Published in: Nanochem Camp 2024, 2024
Publisher: Nanochem Camp

Automated In-Line Separation and Detection of Extracellular Vesicles for Biomarker Validation

Author(s): Brambilla, D.; Autebert, J.; Nazarenko, I.; Unlu, M. S.; Zarovni, N.; Chiari, M.
Published in: ISEV Workshop “EV-based biomarkers: Commercialization and clinical implementation”, 2023
Publisher: ISEV

Conference proceedings (1)

Reversible aptamer-directed immobilization of antibodies and its application in extracellular vesicles separation

Author(s): D. Brambilla; F. Panico; A. Mussida; L. Sola; F. Damin; M. Chiari
Published in: 3rd EVIta Symposium 2023, 2023
Publisher: EVIta Symposium 2023