Closing the European gap towards a large scale ex vivo platelet production built upon a silk-based scaffold bioreactor

Project Information

SilkPlatelet

Grant agreement ID: 101058349

DOI

10.3030/101058349

Project closed

EC signature date 25 July 2022

Start date 1 October 2022

End date 31 December 2025

Funded under

• The European Innovation Council (EIC)

Total cost

€ 1 798 152,50

EU contribution

€ 1 798 152,50

Coordinated by

UNIVERSITA DEGLI STUDI DI PAVIA
Italy

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Deliverables

Other (1)

Web site and Logo

Desgin of the project web site and logo

Publications

Peer reviewed articles (6)

In vitro studies of human erythropoiesis using a 3D silk-based bone marrow model that generates erythroblastic islands

Author(s): Christian A. Di Buduo; Francesca Careddu; Samuele Metti; Marco Lunghi; Santo Diprima; Virginia Camilotto; Giovanna Bruni; Umberto Gianelli; Delfina Tosi; Cesare Perotti; Claudia Del Fante; Mario Cazzo
Published in: Blood Advances, 2025, ISSN 2473-9537
Publisher: Elsevier
DOI: 10.1182/BLOODADVANCES.2024014905

Defective neutrophil clearance in <i>JAK2</i> <i>V617F</i> myeloproliferative neoplasms drives myelofibrosis via immune checkpoint CD24

Author(s): Eman Khatib-Massalha, Christian A. Di Buduo, Agathe L. Chédeville, Ya-Hsuan Ho, Yexuan Zhu, Elodie Grockowiak, Yuki Date, Lam T. Khuat, Zijian Fang, José Quesada-Salas, Eva Carrillo Félez, Matteo M
Published in: Blood, Issue 146, 2025, ISSN 0006-4971
Publisher: American Society of Hematology
DOI: 10.1182/BLOOD.2024027455

Illustrated capsules from the Advanced Course in Platelet Research

Author(s): Christian Andrea Di Buduo, Vittorio Abbonante, Alessandro Malara, Alessandra Balduini, Amie K. Waller, Steve P. Watson, Eleyna M. Martin, Lloyd Bridge, Jonathan Gibbins, Ingeborg Hers, Claire Masson,
Published in: Research and Practice in Thrombosis and Haemostasis, Issue 9, 2025, ISSN 2475-0379
Publisher: Elsevier BV
DOI: 10.1016/J.RPTH.2025.102715

Fluorinated Hydrophobic Silk as Platelet Compatible Coatings for Platelet Conservation and Storage Applications

Author(s): Sanjana Gopalakrishnan, Julia N. Fountain, Christian A. Di Buduo, Haley M. Anchukaitis, Prithviraj Talukdar, Sophie C. Durland, Marco Lunghi, Vittorio Montanari, Alessandra Balduini, Krishna Kumar, Da
Published in: Advanced Functional Materials, Issue 35, 2025, ISSN 1616-301X
Publisher: Wiley
DOI: 10.1002/ADFM.202508074

Dose-dependent effects of eltrombopag iron chelation on platelet formation

Author(s): Elisabetta Bassi; Vittorio Abbonante; Alicia Aguilar; Hana Raslova; James B. Bussel; Christian Andrea Di Buduo; Alessandro Malara; Alessandra Balduini
Published in: Blood Vessels, Thrombosis &amp; Hemostasis, 2025, ISSN 2950-3272
Publisher: Elsevier
DOI: 10.1016/J.BVTH.2025.100060

Inside-to-outside and back to the future of megakaryopoiesis

Author(s): Christian Andrea Di Buduo, Carolina Paula Miguel, Alessandra Balduini
Published in: Research and Practice in Thrombosis and Haemostasis, 2023, ISSN 2475-0379
Publisher: Elsevier
DOI: 10.1016/j.rpth.2023.100197

Conference proceedings (2)

Silk Bone Marrow Niches to Model Fibrosis and Altered Megakaryopoiesis in Myeloproliferative Neoplasms

Author(s): Christian Andrea Di Buduo, Carolina Paula Miguel, Giulia Della Rosa, Vittorio Abbonante, Alessandro Malara, Daniele Cattaneo, Delfina Tosi, Umberto Gianelli, Alessandra Iurlo, Alessandra Balduini
Published in: Blood, Issue 144, 2024, ISSN 0006-4971
Publisher: American Society of Hematology
DOI: 10.1182/BLOOD-2024-209781

3D Silk-Based Bone Marrow Models Identify Autophagy As a Critical Mechanism in Red Blood Cell Production

Author(s): Christian Andrea Di Buduo, Francesca Careddu, Samuele Metti, Cesare Perotti, Claudia Del Fante, Paola Braghetta, Giampaolo Minetti, Luca Malcovati, Alessandra Balduini
Published in: Blood, Issue 144, 2024, ISSN 0006-4971
Publisher: American Society of Hematology
DOI: 10.1182/BLOOD-2024-209731