interTwin is a 36-month project (Sep 2022-Aug 2025) intending to co-design and implement the prototype of an interdisciplinary Digital Twin Engine (DTE) for science. The two main objectives of the project are to develop the DTE (Obj1), allowing to building of complex application-specific Digital Twins (DTs) for the benefit of researchers, business and civil society, and to deliver a Digital Twin Engine Blueprint Architecture (Obj2), providing a conceptual framework for the development of DTs supporting interoperability, performance, portability, and accuracy. As interTwin aims to target researchers via the European Open Science Cloud (EOSC), the services will be made available to EOSC, either onboarded in the EU Node or as services in Thematic Nodes in the new EOSC Nodes Federation (Obj3). One of the main issues when building DTs is also to ensure trustworthy outputs and to ensure reproducibility (Obj4). In addition, interTwin aims at developing the concept of Model Quality Validation as a Service, to enable DT builders to exploit Automation, Continuous Integration and Delivery (CI/CD). As such, a comprehensive environment for Model Quality Assessment and Validation will be created, integrating the evaluation of FAIR data quality, planned for both observed and simulated data. As Data Fusion is an important aspect when building complex simulation applications, interTwin will deliver functional modules for easier integration of different observational data sources and model-generated data (Obj5). Finally, the DTE will deliver tools for experienced and novice DT developers to advance their modelling and simulation applications with AI. The DTE offers capabilities for model creation and update, model training and evaluation. Reinforcing Open Science practices, new models created in the DTE can be exported, reused, and deployed (Obj6).