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Designing green and energy-efficient anti-dewetting protocols for liquid chromatography

Objective

High Performance Liquid Chromatography (HPLC) is the leading separation technology in research and industry, which often relies on potentially hazardous and environmentally harmful organic solvents. Water is the ideal environmentally friendly mobile phase, which would open the way to green HPLC. However, its broad applicability is hindered by the phenomenon of dewetting of the stationary phase – the formation of bubbles in the hydrophobic nanoporous material – which makes it unavailable to the substances that need to be separated (“retention loss”). NODRY proposes to develop a unique, experimentally validated simulation testbed based on the PI expertise in theory and simulation of dewetting of nanopores acquired in ERC-StG HyGate. These simulation tools will be deployed to rationally design HPLC protocols capable of eliminating or alleviating the problem of dewetting in most HPLC columns operating with pure water as the solvent, thus opening the way to a green and energy efficient chromatography.

Coordinator

UNIVERSITA DEGLI STUDI DI ROMA LA SAPIENZA
Net EU contribution
€ 100 000,00
Address
Piazzale Aldo Moro 5
00185 Roma
Italy

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Region
Centro (IT) Lazio Roma
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
No data

Participants (1)

CENTRO DE INVESTIGACION COOPERATIVA DE ENERGIAS ALTERNATIVAS FUNDACION, CIC ENERGIGUNE FUNDAZIOA
Spain
Net EU contribution
€ 50 000,00
Address
Calle Albert Einstein 48 Parque Tecnologico De Alava
01510 Minano Alava

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Region
Noreste País Vasco Araba/Álava
Activity type
Research Organisations
Non-EU contribution
No data