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Designing green and energy-efficient anti-dewetting protocols for liquid chromatography

Obiettivo

High Performance Liquid Chromatography (HPLC) is the leading separation technology in research and industry, which often relies on potentially hazardous and environmentally harmful organic solvents. Water is the ideal environmentally friendly mobile phase, which would open the way to green HPLC. However, its broad applicability is hindered by the phenomenon of dewetting of the stationary phase – the formation of bubbles in the hydrophobic nanoporous material – which makes it unavailable to the substances that need to be separated (“retention loss”). NODRY proposes to develop a unique, experimentally validated simulation testbed based on the PI expertise in theory and simulation of dewetting of nanopores acquired in ERC-StG HyGate. These simulation tools will be deployed to rationally design HPLC protocols capable of eliminating or alleviating the problem of dewetting in most HPLC columns operating with pure water as the solvent, thus opening the way to a green and energy efficient chromatography.

Meccanismo di finanziamento

ERC-POC - Proof of Concept Grant

Istituzione ospitante

UNIVERSITA DEGLI STUDI DI ROMA LA SAPIENZA
Contribution nette de l'UE
€ 100 000,00
Indirizzo
Piazzale Aldo Moro 5
00185 Roma
Italia

Mostra sulla mappa

Regione
Centro (IT) Lazio Roma
Tipo di attività
Higher or Secondary Education Establishments
Collegamenti
Costo totale
Nessun dato

Beneficiari (2)