Central European Advanced Therapy and Immunotherapy Centre

Informations projet

CREATIC

N° de convention de subvention: 101059788

DOI

10.3030/101059788

Date de signature de la CE 27 Avril 2023

Date de début 1 Septembre 2023

Date de fin 31 Août 2029

Financé au titre de

Widening participation and spreading excellence

Coût total

€ 14 999 906,25

Contribution de l’UE

€ 14 999 906,25

14 999 906,25

Coordonné par

Masarykova univerzita
Czechia

CORDIS fournit des liens vers les livrables publics et les publications des projets HORIZON.

Les liens vers les livrables et les publications des projets du 7e PC, ainsi que les liens vers certains types de résultats spécifiques tels que les jeux de données et les logiciels, sont récupérés dynamiquement sur OpenAIRE .

Livrables

CREATIC Statute and Organisational Rules approved

Basic organisational documents of the Centre of Excellence.

CREATIC Open data sets lifecycle strategy
Human potential centred HR strategy including Recruitment and selection rules

HR strategy of the centre.

Quality and Risk Management Plan
C&D&E strategy including brand manual
Project Management Handbook

A document describing the organisational issues of the project implementation (contacts, definition of competences, ways of cooperation between partners, etc.)

CREATIC R&I Strategy

Research and innovation strategy of the Centre of Excellence.

Publications

Exploring the publication gap in pediatric randomized clinical trials: completed vs. uncompleted pediatric clinical trials

Auteurs: Katerina Nebeska, Lenka Souckova, Radka Stepanova, Regina Demlova
Publié dans: Frontiers in Medicine, Numéro 12, 2025, ISSN 2296-858X
Éditeur: Frontiers Media SA
DOI: 10.3389/FMED.2025.1590125

Lost cells, retained structure: proteomic mapping of decellularized lung matrisome across species

Auteurs: Katarína Čimborová, Vendula Pelková, Ondřej Bernatík, David Potěšil, Václav Pustka, Naděžda Vaškovicová, Hana Kotasová, Ladislav Mitáš, Petr Vaňhara, Veronika Sedláková, Zbyněk Zdráhal, Dáša Bohačiaková, Aleš Hampl
Publié dans: Materials & Design, Numéro 270, 2026, ISSN 0264-1275
Éditeur: Elsevier BV
DOI: 10.1016/J.MATDES.2026.116823

Individualized therapeutic approaches for relapsed and refractory pediatric ependymomas: a single institution experience

Auteurs: Pavel Tinka, Petra Pokorná, Michal Kýr, Zdeněk Pavelka, Klára Vejmělková, Hana Pálová, Jakub Neradil, Marta Ježová, Ondřej Slabý, Jaroslav Štěrba
Publié dans: Journal of Neuro-Oncology, Numéro 173, 2025, ISSN 0167-594X
Éditeur: Springer Science and Business Media LLC
DOI: 10.1007/S11060-025-05004-1

What is the problem and what can be done when data sharing challenges public legitimacy?

Auteurs: Klaus Hoeyer, Lea Skovgaard
Publié dans: Nature Communications, Numéro 17, 2026, ISSN 2041-1723
Éditeur: Springer Science and Business Media LLC
DOI: 10.1038/S41467-026-77006-0

Care or Innovation? Studying the Implementation of the Hospital Exemption in Denmark

Auteurs: Z. A. Sheikh, L. Skovgaard, S. Wadmann, J. Wested
Publié dans: European Health & Pharmaceutical Law Review, Numéro 9, 2026, ISSN 2751-3971
Éditeur: Lexxion Verlag
DOI: 10.21552/EHPL/2026/1/6

Health Technology Assessment Guidelines and Recommendations Across European Union Countries and the United Kingdom in Rare Disease and Paediatric Populations

Auteurs: Adéla Bártová, Jiří Samek, Vera Pinheiro, Barbora Říhová, João Vasco Santos
Publié dans: Applied Health Economics and Health Policy, Numéro 24, 2026, ISSN 1175-5652
Éditeur: Springer Science and Business Media LLC
DOI: 10.1007/S40258-025-01008-0

Enhancing pragmatic competence in investigator-initiated clinical trials: structure and evaluation of the CONSCIOUS II training programme

Auteurs: Jitka Rychlíčková, Zora Čechová, Viktoria Nagy, Kateřina Nebeská, Lenka Součková, Stéphane Mouly, Gabor Laszlo Kovacs, Christine Kubiak, Eva Takács, Tiago H. Moreira de Oliveira, Marco Painho, Emília C. Monteiro, Sara Maia, Joana Batuca, Frances Shiely
Publié dans: BMC Medical Education, Numéro 25, 2025, ISSN 1472-6920
Éditeur: Springer Science and Business Media LLC
DOI: 10.1186/S12909-025-07054-5

ATMP Innovation in Europe: An Ecosystem in Active Transition

Auteurs: Z. Čechová, G. Lenarczyk, E.M.S. Nielsen, J. Samek, Z. Afshan Sheikh, L. Skovgaard, J. Wested
Publié dans: European Health & Pharmaceutical Law Review, Numéro 9, 2026, ISSN 2751-3971
Éditeur: Lexxion Verlag
DOI: 10.21552/EHPL/2026/1/8

crossNN is an explainable framework for cross-platform DNA methylation-based classification of tumors

Auteurs: Dongsheng Yuan, Robin Jugas, Petra Pokorna, Jaroslav Sterba, Ondrej Slaby, Simone Schmid, Christin Siewert, Brendan Osberg, David Capper, Skarphedinn Halldorsson, Einar O. Vik-Mo, Pia S. Zeiner, Katharina J. Weber, Patrick N. Harter, Christian Thomas, Anne Albers, Markus Rechsteiner, Regina Reimann, Anton Appelt, Ulrich Schüller, Nabil Jabareen, Sebastian Mackowiak, Naveed Ishaque, Roland Eils, Sören Lukassen, Philipp Euskirchen
Publié dans: Nature Cancer, Numéro 6, 2025, ISSN 2662-1347
Éditeur: Springer Science and Business Media LLC
DOI: 10.1038/S43018-025-00976-5

Implementing performance-based risk-sharing agreements in non-small cell lung cancer immunotherapy: a real-world data case study

Auteurs: Adéla Bártová, Filippo Rumi, João Vasco Santos, Adam Svobodník, Barbora Rihova
Publié dans: Health Economics Review, Numéro 15, 2025, ISSN 2191-1991
Éditeur: Springer Science and Business Media LLC
DOI: 10.1186/S13561-025-00646-3

Real-World Performance of Integrative Clinical Genomics in Pediatric Precision Oncology

Auteurs: Petra Pokorna, Hana Palova, Sona Adamcova, Robin Jugas, Dagmar Al Tukmachi, Michal Kyr, Dana Knoflickova, Katerina Kozelkova, Vojtech Bystry, Sona Mejstrikova, Tomas Merta, Karolina Trachtova, Eliska Podlipna, Peter Mudry, Zdenek Pavelka, Viera Bajciova, Pavel Tinka, Marie Jarosova, Tina Catela Ivkovic, Sibylle Madlener, Karol Pal, Natalia Stepien, Lisa Mayr, Boris Tichy, Klara Drabova, Marta Jezova, Sarka Kozakova, Jitka Vanackova, Lenka Radova, Karin Steininger, Christine Haberler, Johannes Gojo, Jaroslav Sterba, Ondrej Slaby
Publié dans: Laboratory Investigation, Numéro 104, 2024, ISSN 0023-6837
Éditeur: Elsevier BV
DOI: 10.1016/J.LABINV.2024.102161

Real‐World Data From a Molecular Tumor Board‐Assisted Cancer Care From a Single Center in The Czech Republic: Is Precision Oncology an Accessible Option, or a Privilege for a Minority of Patients?

Auteurs: Michal Eid, Markéta Bednaříková, Jakub Vlažný, Jitka Hausnerová, Renata Taslerová, Sára Vilmanová, Martina Jelínková, Alena Homolová, Martin Gryc, Jakub Trizuljak, Zdeněk Pavlovský, Štěpán Tuček, Dagmar Brančíková, Monika Bratová, Tomáš Rohan, Zdeněk Kala, Zdeněk Král, Jiří Mayer, Adam Svobodník, Ondřej Slabý
Publié dans: Cancer Medicine, Numéro 14, 2025, ISSN 2045-7634
Éditeur: Wiley
DOI: 10.1002/CAM4.71119

End-to-end workflows for liquid biopsy biotyping analysis using combined MALDI MS and machine learning approach

Auteurs: Lukáš Pečinka, Jaromíra Pantůčková, Monika Vlachová, Lukáš Moráň, Tereza Růžičková, Petra Weselá, Lubomír Prokeš, Josef Havel, Luděk Pour, Sabina Ševčíková, Petr Vaňhara
Publié dans: Analytical Methods, Numéro 17, 2025, ISSN 1759-9660
Éditeur: Royal Society of Chemistry , Burlington HousePiccadillyLondonW1J 0BAUnited Kingdom
DOI: 10.1039/D5AY01299F

Photostimulation improves maturation of human photoreceptors

Auteurs: Canan Celiker, Eva Hruba, Konstantina Kyriakou, Birthe Dorgau, Francisco Molina Gambin, Kamila Weissova, Edwin van Oosten, Lucie Englmaier, Nadezda Vaskovicova, Michael A. Savage, Gerrit Hilgen, Evelyne Sernagor, Alejandro Garanto, Majlinda Lako, Tomas Barta
Publié dans: Nature Communications, Numéro 17, 2026, ISSN 2041-1723
Éditeur: Springer Science and Business Media LLC
DOI: 10.1038/S41467-026-76112-3

Long-term daily light exposure boosts human retinal organoid differentiation

Auteurs: Edwin M. van Oosten, Wietske Kieboom, Anita D. M. Hoogendoorn, Stijn L. Berendsen, Julia Haerkens, Marieke M. E. van der Maden, Eva Hruba, Devin Veerman, Anja Bufe, Seba Almedawar, Andries D. van der Meer, Tomas Barta, Rob W. J. Collin, Alejandro Garanto
Publié dans: Communications Biology, Numéro 9, 2026, ISSN 2399-3642
Éditeur: Springer Science and Business Media LLC
DOI: 10.1038/S42003-026-10216-W

Circulating Serum piRNAs as Diagnostic and Prognostic Tools for Clear Cell Renal Cell Carcinoma

Auteurs: MAREK KASIK, ROBERT ILIEV, PETRA VYCHYTILOVA, SILVIA RYBECKA, LENKA RADOVA, MICHAL STANIK, MICHAL FEDORKO, JAN DOLEZEL, ONDREJ SLABY, JULIA BOHOSOVA
Publié dans: Cancer Genomics - Proteomics, Numéro 22, 2025, ISSN 1109-6535
Éditeur: International Institute of Anticancer Research
DOI: 10.21873/CGP.20545

Waiting as a frontier: (Un)making patients for uterus transplantation in Denmark

Auteurs: Zainab Afshan Sheikh, Alexandra Middleton, Anja M.B. Jensen
Publié dans: Social Science & Medicine, Numéro 401, 2026, ISSN 0277-9536
Éditeur: Elsevier BV
DOI: 10.1016/J.SOCSCIMED.2026.119291

Emergency medicine pharmacotherapy compromises accuracy of plasma creatinine determination by enzyme-based methods: real-world clinical evidence and implications for clinical practice

Auteurs: Regina Demlova; Sarka Kozakova; Sarka Kozakova; Michal Rihacek; Michal Rihacek; Michal Rihacek; Dana Buckova; Dana Buckova; Katerina Horska; Katerina Horska; Ondrej Wiewiorka; Ondrej Wiewiorka; Lubos Boucek; Iveta Selingerova; Iveta Selingerova; Martina Podborska; Martina Podborska; Alena Korberova; Alena Korberova; Alena Mikuskova; Alena Mikuskova; Jiri Starha; Jiri Starha; Miroslava Benovska; Miroslava Benovska; Martin Radina; Martin Radina; Martin Radina; Michal Richter; Lenka Zdrazilova Dubska; Lenka Zdrazilova Dubska; Lenka Zdrazilova Dubska; Dalibor Valik; Dalibor Valik; Dalibor Valik; Dalibor Valik
Publié dans: Frontiers in Medicine, 2024, ISSN 2296-858X
Éditeur: FRONTIERS MEDIA SAAVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE CH-1015, SWITZERLAND
DOI: 10.3389/FMED.2023.1236948

Correct sample collection as the basis for reliable laboratory diagnostics: avoid common mistakes

Auteurs: Dominika Zhánělová, Martina Mrkvicová, Lenka Zdražilová-Dubská
Publié dans: Medicína pro praxi, Numéro 22, 2025, ISSN 1214-8687
Éditeur: Solen s.r.o.
DOI: 10.36290/MED.2025.041

Scientific Reports

Auteurs: Katerina Slaba; Petra Pokorna; Robin Jugas; Hana Palova; Dagmar Prochazkova; Stefania Aulicka; Klara Spanelova; Pavlina Danhofer; Ondrej Horak; Jana Tuckova; Petra Kleiblova; Renata Gaillyova; Matej Hrunka; Martin Jouza; Blanka Pinkova; Jan Papez; Petra Konecna; Jana Zidkova; Petr Stourac; Jaroslav Sterba; Regina Demlova; Eva Demlova; Petr Jabandziev; Ondrej Slaby
Publié dans: Scientific Reports, 2024, ISSN 2045-2322
Éditeur: NATURE PORTFOLIOHEIDELBERGER PLATZ 3, BERLIN 14197, GERMANY
DOI: 10.1038/S41598-024-79872-4

Evaluation of Anti-CAR Linker mAbs for CAR T Monitoring after BiTEs/bsAbs and CAR T-Cell Pretreatment

Auteurs: Anja Grahnert; Sabine Seiffert; Kerstin Wenk; Dominik Schmiedel; Andreas Boldt; Vladan Vucinic; Maximilian Merz; Uwe Platzbecker; Christian Klemann; Ulrike Koehl; Maik Friedrich
Publié dans: Biomedicines, 2024, ISSN 2227-9059
Éditeur: MDPIST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
DOI: 10.20944/PREPRINTS202407.0787.V1

Challenges and perspectives in the diagnosis of undiagnosed pediatric patients and an overview of therapeutic options in rare diseases

Auteurs: Kateřina Slabá, Petra Pokorná, Kamila Říhová, Regina Demlová, Ondřej Slabý
Publié dans: Neurologie pro praxi, Numéro 27, 2026, ISSN 1213-1814
Éditeur: Solen s.r.o.
DOI: 10.36290/NEU.2026.017

Aicardi‐Goutières Syndrome Type 6: Case Report and Structural Prediction Supporting a Dominant‐Negative Effect of the <i>ADAR1</i> c. <i>3019G</i> >A Variant

Auteurs: Katerina Turan, Petra Pokorna, Kamila Rihova, Jana Kubatova, Katerina Kozelkova, Eliska Hlouskova, Pavlina Danhofer, Petr Jabandziev, Jiri Damborsky, Regina Demlova, Ondrej Slaby, Katerina Slaba
Publié dans: Clinical Case Reports, Numéro 14, 2026, ISSN 2050-0904
Éditeur: John Wiley & Sons, Ltd Wiley-Blackwell111 River StreetHoboken, NJ 07030-5774USA
DOI: 10.1002/CCR3.72146

Factors associated with the content of phenolic compounds in the genus Salix: the role of species, plant organ, season, and soil parameters

Auteurs: Dorota Gawenda-Kempczyńska, Krystian Krolik, Jakub Gębalski, Maciej Strzemski, Maciej Markiewicz, Filip Graczyk, Ivan Kushkevych, Paulina Drapińska, Daniel Załuski
Publié dans: BMC Plant Biology, 2026, ISSN 1471-2229
Éditeur: Springer Science and Business Media LLC
DOI: 10.1186/S12870-026-09918-4

Correlation of FSTL1 and its paralogs with body composition in adult survivors of childhood cancer

Auteurs: Lucie Štrublová, Filip Zlámal, Tomáš Pískovský, Jan Kučera, Jana Fialová Kučerová, Tomáš Kepák, Jaroslav Štěrba, Julie Bienertová-Vašků
Publié dans: Scientific Reports, Numéro 15, 2025, ISSN 2045-2322
Éditeur: Springer Science and Business Media LLC
DOI: 10.1038/S41598-025-03013-8

A longitudinal single-cell atlas to predict outcome and toxicity after BCMA-directed CAR T cell therapy in multiple myeloma

Auteurs: Michael Rade, David Fandrei, Markus Kreuz, Sabine Seiffert, Anja Grahnert, Maik Friedrich, Thomas Wiemers, Patrick Born, Luise Fischer, Heike Weidner, Lorenz C. Hofbauer, Ronny Baber, Song Yau Wang, Enrica Bach, Sandra Hoffmann, Jonathan Scolnick, Mirco Friedrich, Farid Keramati, Peter Brazda, Zsolt Sebestyen, Jürgen Kuball, Miriam Alb, Lukas Scheller, Michael Hudecek, Hermann Einsele, Klaus H. Metzeler, Marco Herling, Carmen Diana Herling, Madlen Jentzsch, Georg-Nikolaus Franke, Andreas Boldt, Ulrike Köhl, Uwe Platzbecker, Vladan Vucinic, Kristin Reiche, Maximilian Merz
Publié dans: Cancer Cell, Numéro 44, 2026, ISSN 1535-6108
Éditeur: Elsevier BV
DOI: 10.1016/J.CCELL.2025.10.014

ReNU syndrome - a newly described prevalent neurodevelopmental disorder: first case in the Czech Republic

Auteurs: Kateřina Slabá, Petra Pokorná, Kateřina Koželková, Eliška Hloušková, Robin Jugas, Jana Kubátová, Regina Demlová, Pavlína Danhofer, Petr Jabandžiev, Tereza Svatoňová, Ondřej Slabý
Publié dans: Česko-slovenská pediatrie, Numéro 80, 2025, ISSN 0069-2328
Éditeur: Galen, spol. s r.o.
DOI: 10.55095/CSPEDIATRIE2025/029

Lipopolysaccharide induces retention of E-cadherin in the endoplasmic reticulum and promotes hybrid epithelial-to-mesenchymal transition of human embryonic stem cells-derived expandable lung epithelial cells

Auteurs: Türkan Portakal, Vítězslav Havlíček, Jarmila Herůdková, Vendula Pelková, Tereza Gruntová, Rıza Can Çakmakci, Hana Kotasová, Aleš Hampl, Petr Vaňhara
Publié dans: Inflammation Research, Numéro 74, 2025, ISSN 1023-3830
Éditeur: Springer Science and Business Media LLC
DOI: 10.1007/S00011-025-02041-4

Beyond Reimbursement Status: Availability of Advanced Therapy Medicinal Products Across the European Union

Auteurs: Zora Čechová, Jana Kubátová, Adéla Bártová, Jakub Jamárik, Jiří Samek
Publié dans: Therapeutic Innovation & Regulatory Science, Numéro 59, 2025, ISSN 2168-4790
Éditeur: SPRINGER HEIDELBERGTIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
DOI: 10.1007/S43441-025-00769-Z

Cell Invasion Analysis of Tumor Spheroids Using 2D Image Data

Auteurs: Matěj Přikryl, Andrea Rousová, Ivana Acimovic, Petr Vaňhara, Lukáš Jan, Petr Beneš, Jan Šmarda, Michal Kozubek, Karel Štěpka, Jarmila Navrátilová
Publié dans: ACS Measurement Science Au, Numéro 6, 2026, ISSN 2694-250X
Éditeur: American Chemical Society (ACS)
DOI: 10.1021/ACSMEASURESCIAU.5C00121

Serum Levels of CA125 and HE4 as a Tool for Predicting Regional Lymph Node Metastatic Involvement in Endometrial Carcinoma

Auteurs: Tomáš Crha, Petra Ovesná, Vít Weinberger, Michal Felsinger, Branislav Babjak, Dalibor Valík, Jitka Hausnerová, Luboš Minář
Publié dans: Cancers, Numéro 17, 2025, ISSN 2072-6694
Éditeur: MDPIMDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
DOI: 10.3390/CANCERS17172740

Patterns of SARS-CoV-2-specific humoral and cellular immune response in actively treated patients with solid cancer following prime BNT162b2 COVID-19 vaccination: results from phase IV CoVigi trial

Auteurs: Radka Lordick Obermannova, Iveta Selingerova, Regina Demlova, Dominika Okruhlicova, Jiri Nevrlka, Katerina Cerna-Pilatova, Kristina Greplova, Zdenka Cermakova, Dalibor Valik, Igor Kiss, Marketa Palacova, Alexandr Poprach, Hana Lejdarova, Sarka Selvekerova, Martina Vaneckova, Lenka Zdrazilova-Dubska
Publié dans: Therapeutic Advances in Medical Oncology, Numéro 17, 2026, ISSN 1758-8359
Éditeur: SAGE Publications, 2455 Teller RoadThousand Oaks, CA 91320USA
DOI: 10.1177/17588359251316224

International Journal of Cancer

Auteurs: Michal Kyr; Peter Mudry; Kristyna Polaskova; Lenka Zdrazilova Dubska; Regina Demlova; Jana Kubatova; Eva Hlavackova; Katerina Cerna Pilatova; Pavel Mazanek; Klara Vejmelkova; Vitezslav Dusek; Pavel Tinka; Martin Balaz; Tomas Merta; Zuzana Kuttnerova; Terezia Turekova; Zdenek Pavelka; Petra Pokorna; Hana Palova; Marie Mlnarikova; Marta Jezova; Renata Kellnerova; Sarka Kozakova; Ondrej Slaby; Dalibor Valik; Jaroslav Sterba
Publié dans: International Journal of Cancer, 2024, ISSN 0020-7136
Éditeur: John Wiley & Sons Inc.
DOI: 10.1002/IJC.35062

Lymphopenia in glioblastoma and its association with brain vessel irradiation: pilot retrospective evaluation of dose-volume parameters

Auteurs: Lucie Hnidakova, Iveta Selingerova, Petr Pospisil, Jana Halamkova, Renata Belanova, Tomas Nikl, Jiri Sana, Barbora Vavrusakova, Renata Bartosova, Ondrej Slaby, Pavel Slampa, Radim Jancalek, Giuseppe Minniti, Tomas Kazda
Publié dans: Neoplasma, Numéro 72, 2025, ISSN 1338-4317
Éditeur: AEPress, s.r.o.
DOI: 10.4149/NEO_2025_250730N330

Unveiling the cellular and molecular mechanisms of diabetic retinopathy with human retinal organoids

Auteurs: Lada Polešovská, Simona Trmačová, Canan Celiker, Eva Hrubá, Francisco Molina Gambin, Václav Chochola, Veronika Matušková, Eleni Beli, Tomáš Bárta
Publié dans: Cell Death & Disease, Numéro 16, 2025, ISSN 2041-4889
Éditeur: Springer Science and Business Media LLC
DOI: 10.1038/S41419-025-08244-1

Artificial intelligence in pancreatic cancer histopathology and diagnostics - implications for clinical decisions and biomarker discovery?

Auteurs: Petra Weselá, Michal Eid, Petr Moravčík, Jakub Vlažný, Jan Hlavsa, Vladimír Procházka, Zdeněk Kala, Petr Vaňhara
Publié dans: Cell Division, Numéro 20, 2025, ISSN 1747-1028
Éditeur: Springer Science and Business Media LLC
DOI: 10.1186/S13008-025-00158-W

Non-Saccharomyces Yeasts as a Tool for Modulating the Aromatic and Sensory Profile of Mead

Auteurs: Nenad Jevremović, Bojana Danilović, Stojan Mančić, Marko Malićanin, Dani Dordevic, Ivana Karabegović, Ivan Kushkevych
Publié dans: Processes, Numéro 14, 2026, ISSN 2227-9717
Éditeur: MDPI AG
DOI: 10.3390/PR14203269

Faecal microbiota transplant - treatment method, transplantation, or administration of medicinal product?

Auteurs: KUBÁTOVÁ, Jana, Iva KOCMANOVÁ, Veronika KOLÁŘOVÁ, Julie CHVÁTALOVÁ, Lenka ZDRAŽILOVÁ DUBSKÁ a Regina DEMLOVÁ
Publié dans: I. Společná konference farmakologických společností 2024., 2024

Droits de propriété intellectuelle

FAIR MEDICINE by CREATIC

Numéro de demande/publication: EUTM 019091883
Date: 2024-10-16
Demandeur(s): Masarykova univerzita

FlyCellix

Numéro de demande/publication: EUTM 019091286
Date: 2024-10-15
Demandeur(s): Masarykova univerzita

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