BIOLOC recognises the unique value of local knowledge in advancing the circular bioeconomy. Although new technologies are often deployed following traditional industrial patterns, this may limit the potential of a paradigm rooted in territorial anchoring. Local actors are not only suppliers or consumers of biomass; they are holders of contextual knowledge essential for building sustainable, resilient, and innovative CBE ecosystems. BIOLOC stands out for exploring the intersection between techno-economic models and societal enabling factors. Its objective is to strengthen the role of social innovation and inclusion in revitalising local economies across 12 European regions. Through multisectoral research and extensive quadruple-helix co-creation, the project examined societal drivers supporting the transition from fossil-based to circular biobased systems and developed measures to foster inclusion and participatory innovation in the target regions. To address territorial diversity, BIOLOC applied clustering analysis, capturing environmental, economic, and social differences. Building on this assessment, BIOLOC conceptualised an approach to evaluate innovation maturity beyond technological performance, incorporating aspects such as market readiness, governance conditions, and cultural perceptions. This led to the development of an innovative Societal Readiness Level (SRL) concept, intended to complement conventional assessments by integrating institutional preparedness and societal acceptance. BIOLOC’s collaborative dimension is demonstrated by the establishment of 12 Regional Hubs, which structure social dialogue around inclusive CBE. The Hubs provide region-specific intelligence on biomass potential, development strategies, policy frameworks, and socio-economic conditions. They identify drivers and barriers for involving vulnerable groups and analyse the engagement dynamics of marginalised communities, including capacity-enhancement needs. As focal points of co-creation, they tailor BIOLOC’s solutions to local conditions and inform regional innovation processes. BIOLOC’s outcomes highlight its catalytic role in promoting educational outreach, inclusive policy formulation, and community-driven initiatives, contributing to a more equitable and sustainable CBE landscape. Its commitment to innovation and collaboration is reshaping the involvement of marginalised groups and strengthening the social dimension of regional circular transitions.