Accurate diagnosis and prognosis of Alzheimer’s disease in primary care

Informations projet

ADetect

N° de convention de subvention: 101061836

DOI

10.3030/101061836

Projet clôturé

Date de signature de la CE 1 Août 2022

Date de début 1 Octobre 2022

Date de fin 30 Septembre 2024

Financé au titre de

• Marie Skłodowska-Curie Actions (MSCA)

Coût total

Aucune donnée

Contribution de l’UE

€ 206 887,68

Coordonné par

LUNDS UNIVERSITET
Sweden

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Livrables

Documents, reports (2)

Communication, Dissemination & Exploitation Plan

The plan describes the planned measures to maximize the impact of the project, including the dissemination and exploitation measures that are planned, and the target group(s) addressed. Regarding communication measures and public engagement strategy, the aim is to inform and reach out to society and show the activities performed, and the use and the benefits the project will have for citizens.

Data Management Plan

The Data Management Plan describes the data management life cycle for all data sets that will be collected, processed or generated by the action. It is a document describing what data will be collected, processed or generated and following what methodology and standards, whether and how this data will be shared and/or made open, and how it will be curated and preserved

Publications

Peer reviewed articles (11)

Highly accurate blood test for Alzheimer’s disease is similar or superior to clinical cerebrospinal fluid tests

Auteurs: Nicolas R. Barthélemy, Gemma Salvadó, Suzanne E. Schindler, Yingxin He, Shorena Janelidze, Lyduine E. Collij, Benjamin Saef, Rachel L. Henson, Charles D. Chen, Brian A. Gordon, Yan Li, Renaud La Joie, Tammie L. S. Benzinger, John C. Morris, Niklas Mattsson-Carlgren, Sebastian Palmqvist, Rik Ossenkoppele, Gil D. Rabinovici, Erik Stomrud, Randall J. Bateman, Oskar Hansson
Publié dans: Nature Medicine, Numéro 30, 2024, ISSN 1078-8956
Éditeur: Springer Science and Business Media LLC
DOI: 10.1038/s41591-024-02869-z

Biomarker-based staging of Alzheimer disease: rationale and clinical applications

Auteurs: Joseph Therriault, Suzanne E. Schindler, Gemma Salvadó, Tharick A. Pascoal, Andréa Lessa Benedet, Nicholas J. Ashton, Thomas K. Karikari, Liana Apostolova, Melissa E. Murray, Inge Verberk, Jacob W. Vogel, Renaud La Joie, Serge Gauthier, Charlotte Teunissen, Gil D. Rabinovici, Henrik Zetterberg, Randall J. Bateman, Philip Scheltens, Kaj Blennow, Reisa Sperling, Oskar Hansson, Clifford R. Jack, Pedro Rosa-Neto
Publié dans: Nature Reviews Neurology, Numéro 20, 2024, ISSN 1759-4758
Éditeur: Springer Science and Business Media LLC
DOI: 10.1038/s41582-024-00942-2

CSF MTBR-tau243 is a specific biomarker of tau tangle pathology in Alzheimer’s disease

Auteurs: Kanta Horie, Gemma Salvadó, Nicolas R. Barthélemy, Shorena Janelidze, Yan Li, Yingxin He, Benjamin Saef, Charles D. Chen, Hong Jiang, Olof Strandberg, Alexa Pichet Binette, Sebastian Palmqvist, Chihiro Sato, Pallavi Sachdev, Akihiko Koyama, Brian A. Gordon, Tammie L. S. Benzinger, David M. Holtzman, John C. Morris, Niklas Mattsson-Carlgren, Erik Stomrud, Rik Ossenkoppele, Suzanne E. Schindler, Oskar Hansson, Randall J. Bateman
Publié dans: Nature Medicine, Numéro 29, 2023, ISSN 1078-8956
Éditeur: Springer Science and Business Media LLC
DOI: 10.1038/s41591-023-02443-z

Comparison of immunoassay- with mass spectrometry-derived p-tau quantification for the detection of Alzheimer’s disease pathology

Auteurs: Joseph Therriault, Marcel S. Woo, Gemma Salvadó, Johan Gobom, Thomas K. Karikari, Shorena Janelidze, Stijn Servaes, Nesrine Rahmouni, Cécile Tissot, Nicholas J. Ashton, Andréa Lessa Benedet, Laia Montoliu-Gaya, Arthur C. Macedo, Firoza Z. Lussier, Jenna Stevenson, Paolo Vitali, Manuel A. Friese, Gassan Massarweh, Jean-Paul Soucy, Tharick A. Pascoal, Erik Stomrud, Sebastian Palmqvist, Niklas Mattsson-Carlgren, Serge Gauthier, Henrik Zetterberg, Oskar Hansson, Kaj Blennow, Pedro Rosa-Neto
Publié dans: Molecular Neurodegeneration, Numéro 19, 2024, ISSN 1750-1326
Éditeur: Springer Science and Business Media LLC
DOI: 10.1186/s13024-023-00689-2

Plasma N-terminal containing tau fragments (NTA-tau): a biomarker of tau deposition in Alzheimer’s Disease

Auteurs: Juan Lantero-Rodriguez, Gemma Salvadó, Anniina Snellman, Laia Montoliu-Gaya, Wagner S. Brum, Andrea L. Benedet, Niklas Mattsson-Carlgren, Pontus Tideman, Shorena Janelidze, Sebastian Palmqvist, Erik Stomrud, Nicholas J. Ashton, Henrik Zetterberg, Kaj Blennow, Oskar Hansson
Publié dans: Molecular Neurodegeneration, Numéro 19, 2024, ISSN 1750-1326
Éditeur: Springer Science and Business Media LLC
DOI: 10.1186/s13024-024-00707-x

Optimal combinations of CSF biomarkers for predicting cognitive decline and clinical conversion in cognitively unimpaired participants and mild cognitive impairment patients: A multi‐cohort study

Auteurs: Gemma Salvadó, Victoria Larsson, Karly A Cody, Nicholas C Cullen, Erin M Jonaitis, Erik Stomrud, Gwendlyn Kollmorgen, Norbert Wild, Sebastian Palmqvist, Shorena Janelidze, Niklas Mattsson‐Carlgren, Henrik Zetterberg, Kaj Blennow, Sterling C Johnson, Rik Ossenkoppele, Oskar Hansson
Publié dans: Alzheimer's & Dementia, Numéro 19, 2023, ISSN 1552-5260
Éditeur: Wiley
DOI: 10.1002/alz.12907

Prediction of Longitudinal Cognitive Decline in Preclinical Alzheimer Disease Using Plasma Biomarkers

Auteurs: Niklas Mattsson-Carlgren, Gemma Salvadó, Nicholas J. Ashton, Pontus Tideman, Erik Stomrud, Henrik Zetterberg, Rik Ossenkoppele, Tobey J. Betthauser, Karly Alex Cody, Erin M. Jonaitis, Rebecca Langhough, Sebastian Palmqvist, Kaj Blennow, Shorena Janelidze, Sterling C. Johnson, Oskar Hansson
Publié dans: JAMA Neurology, Numéro 80, 2023, ISSN 2168-6149
Éditeur: American Medical Association (AMA)
DOI: 10.1001/jamaneurol.2022.5272

CSF tau phosphorylation occupancies at T217 and T205 represent improved biomarkers of amyloid and tau pathology in Alzheimer’s disease

Auteurs: Nicolas R. Barthélemy, Benjamin Saef, Yan Li, Brian A. Gordon, Yingxin He, Kanta Horie, Erik Stomrud, Gemma Salvadó, Shorena Janelidze, Chihiro Sato, Vitaliy Ovod, Rachel L. Henson, Anne M. Fagan, Tammie L. S. Benzinger, Chengjie Xiong, John C. Morris, Oskar Hansson, Randall J. Bateman, Suzanne E. Schindler
Publié dans: Nature Aging, Numéro 3, 2023, ISSN 2662-8465
Éditeur: Springer Science and Business Media LLC
DOI: 10.1038/s43587-023-00380-7

Disease staging of Alzheimer’s disease using a CSF-based biomarker model

Auteurs: Gemma Salvadó, Kanta Horie, Nicolas R. Barthélemy, Jacob W. Vogel, Alexa Pichet Binette, Charles D. Chen, Andrew J. Aschenbrenner, Brian A. Gordon, Tammie L. S. Benzinger, David M. Holtzman, John C. Morris, Sebastian Palmqvist, Erik Stomrud, Shorena Janelidze, Rik Ossenkoppele, Suzanne E. Schindler, Randall J. Bateman, Oskar Hansson
Publié dans: Nature Aging, Numéro 4, 2024, ISSN 2662-8465
Éditeur: Springer Science and Business Media LLC
DOI: 10.1038/s43587-024-00599-y

Blood Biomarkers to Detect Alzheimer Disease in Primary Care and Secondary Care

Auteurs: Sebastian Palmqvist, Pontus Tideman, Niklas Mattsson-Carlgren, Suzanne E. Schindler, Ruben Smith, Rik Ossenkoppele, Susanna Calling, Tim West, Mark Monane, Philip B. Verghese, Joel B. Braunstein, Kaj Blennow, Shorena Janelidze, Erik Stomrud, Gemma Salvadó, Oskar Hansson
Publié dans: JAMA, 2024, ISSN 0098-7484
Éditeur: American Medical Association (AMA)
DOI: 10.1001/jama.2024.13855

Specific associations between plasma biomarkers and postmortem amyloid plaque and tau tangle loads

Auteurs: Gemma Salvadó, Rik Ossenkoppele, Nicholas J Ashton, Thomas G Beach, Geidy E Serrano, Eric M Reiman, Henrik Zetterberg, Niklas Mattsson‐Carlgren, Shorena Janelidze, Kaj Blennow, Oskar Hansson
Publié dans: EMBO Molecular Medicine, Numéro 15, 2023, ISSN 1757-4676
Éditeur: Springer Science and Business Media LLC
DOI: 10.15252/emmm.202217123