Project description
Machine learning pipeline to improve prognostic value of DO-VOT analysis
Funded by the Marie Skłodowska-Curie Actions programme, the MACLEA-ENDO project aims to explore the prognostic value of microcirculatory parameters as measured by diffuse optics during a vascular occlusion test (VOT) performed at muscle peripheral level. These parameters, related to tissue perfusion and metabolism, demonstrated their prognostic potential in critical conditions such as acute respiratory diseases, sepsis and in predicting extubation failure in mechanically ventilated patients. In this framework, the project will evaluate a supervised machine learning pipeline for improving VOT-based analysis and the prognostic value of VOT–diffuse optics derived parameters utilising the data from the Horizon2020 project VASCOVID, filling a wide range of clinical needs, from patients' response to endothelium-targeting treatments and outcome prediction.
Objective
Endothelial cells form the lining of the blood vessels of the entire vascular system, from the heart to the smallest capillary, regulating vascular tone, immune response and exchange of materials in and out the blood stream among others. Endothelial damage has been observed in the early stages of most cardiovascular diseases, atherosclerosis or in patients with iflammatory and infectious diseases (e.g. COVID-19, septic shock). Typically endothelial damage is measured by means of blood test analysis and provocative tests either invasive, performed by using pharmacological agents, or non-invasive, such as flow mediated dilation that on the other hand, suffer from high operator-independency and no-automatization. This proposal revolves around the design, development and validation of a supervised machine learning algorithm (ML) to evaluate endothelial damage and predict adverse outcome in critically ill patients in the ICU. The ML pipeline will use as input data the one from the Horizon 2020 project VASCOVID clinical validation. These data comprises of physiologically relevant variables that can be measured non-invasively with a completely automatized platform. This smart platform combines diffuse optics and an automatized tourniquet for performing a reactive test on peripheral muscle (thenar muscle). By means of this device it is possible to access in an accurate and robust way information about early impairment in perfusion, metabolic rate of oxygen consumption, and microvascular functionality and tissue capability of locally regulate the blood flow. These variables bring an important physiological insight concerning the interpretability of machine learning algorithm from the clinical community who does not fully trust this approaches.
Fields of science
- medical and health scienceshealth sciencesinfectious diseases
- medical and health sciencesclinical medicinecardiologycardiovascular diseasesarteriosclerosis
- medical and health sciencesbasic medicineimmunology
- engineering and technologymedical engineeringmedical laboratory technologylaboratory samples analysis
- natural sciencescomputer and information sciencesartificial intelligencemachine learning
Keywords
Programme(s)
- HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA) Main Programme
Funding Scheme
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European FellowshipsCoordinator
08860 Castelldefels
Spain