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Photochemical organocatalytic atropselective processes for the sustainable synthesis of biorelevant axially chiral molecules

Objective

Chiral molecules containing axes of chirality (known as atropisomers) are present in natural products, bioactive molecules, and functional materials. Their increasingly important role in pharmaceuticals means that effective asymmetric strategies are needed for their preparation. However, the available catalytic methods rely on ionic pathways, which limits the diversity of atropisomers that can be achieved. This project seeks to close this gap in asymmetric methodology by providing new catalytic techniques for atropselective synthesis, based on radical chemistry, to greatly boost the impact of axially chiral compounds in drug discovery. We aim to develop methods that combine enantioselective organocatalysis with visible light photochemistry, two powerful strategies with extraordinary potential for the sustainable preparation of chiral molecules. Achieving this target would also address the key synthetic challenge of developing light-driven atropselective processes proceeding via radical pathways.
The research will combine the host’s expertise in photochemistry and radical reactions with the applicant’s background in asymmetric organocatalysis. The resulting strategies will be used as a platform for assembling libraries of atropisomeric compounds that, together with biological screening carried out in collaboration with the pharmaceutical company Bayer AG, will increase the probability of success in identifying drug-candidate structures. The PHOTO-ATROP project is unique because it provides training in “organocatalysis” and “photochemistry applied to drug discovery”, thus contributing to European excellence and sustainability. Its multicultural nature will broaden the fellow’s competencies and place him in a competitive position for his next career move

Coordinator

ALMA MATER STUDIORUM - UNIVERSITA DI BOLOGNA
Net EU contribution
€ 172 750,08
Address
Via Zamboni 33
40126 Bologna
Italy

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Region
Nord-Est Emilia-Romagna Bologna
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
No data