Project description
Systems medicine approach to investigate metabolic factors affecting atherosclerosis development
Funded by the Marie Skłodowska-Curie Actions programme, the IMPACT project will use a systems medicine approach to develop therapeutic approaches for atherosclerotic cardiovascular disease (ACVD) and evaluate factors that contribute to cholesterol metabolism. The project will create a linear programming (LP) algorithm for models of human and microbiome metabolism and to identify optimal microbes and nutrients affecting specific metabolic pathways. The model of cholesterol metabolism will be trained and validated using human data. The in-silico analysis will identify metabolic pathways, microbiome composition, diet, and their influence on cholesterol metabolism and ACVD risks. The metabolic pathways will be analysed using the LP algorithm to discover microbial and nutritional therapies preventing the progression of ACVD.
Objective
Cardiovascular disease (CVD) claims 17.9 million lives and costs the European economy €210 billion annually. New, innovative strategies are needed to address this health crisis. IMPACT takes a systems medicine approach to extend our understanding of the factors that contribute to cholesterol metabolism and to develop innovative therapeutic approaches for atherosclerotic cardiovascular disease (ACVD). IMPACT has three objectives: 1) Develop an LP algorithm that analyzes models of human and microbiome metabolism to identify optimal microbes and nutrients that may influence metabolic pathways of interest. 2) Develop a detailed model of cholesterol metabolism, that is trained and validated using human data, by synergistically merging FBA models with an ordinary differential equation (ODE) model of cholesterol transport. Simulations and statistical analysis on the in-silico results will be conducted to identify metabolic pathways related to ACVD and to investigate how variables such as microbiome composition, sex, obesity, and diet influence cholesterol metabolism and ACVD risk. 3) Metabolic pathways related to ACVD risk will be targeted by the LP algorithm to identify optimal microbial and nutritional therapies that can treat and/or diminish the progression of ACVD. Promising bacterial strains and nutrients will be tested with in-vivo gut simulators in an intersectoral secondment with International Flavors & Fragrances Inc. Results of the proposed research will be effectively disseminated and exploited to maximize IMPACT. While the action serves to extend the state-of-the-art and address a health crisis, IMPACT will simultaneously expand my technical knowledge and transferable skills, bolster my credentials and enhance my career competitiveness through intersectoral exposure.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2021-PF-01
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
H91 Galway
Ireland
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.