Project description
Investigating how Piezo1 channels transform mechanical stimuli into biochemical signals
The ability to remotely control intracellular pathways has opened the way to exciting applications both in the theoretical and experimental regime. The combined use of magnetic fields and magnetic nanoparticles serves as a powerful tool for studying how cells transform mechanical stimuli into biochemical signals. This process that is called mechanotransduction also allows manipulating biological functions with high spatiotemporal control at a deep-tissue level, which is relevant for regenerative medicine. Funded by the Marie Skłodowska-Curie Actions programme, the MAGPIEZ project plans to develop a novel platform to study mechanotransduction linked to Piezo1 channels in endothelial cells. Another goal is to validate the potential of this methodology to stimulate signalling pathways related to cell proliferation to selectively boost angiogenesis.
Objective
During the last decade, the possibility to remotely control intracellular pathways using physical tools has opened the way to exciting applications, both in basic research and clinical applications. The use of magnetic fields in combination with magnetic nanoparticles provides with an exclusive tool to study how cells transform mechanical stimuli into biochemical signals, shedding light on these mechanotransduction processes. This tool is emerging as a new instrument to remotely manipulate biological functions with high spatiotemporal control at a deep-tissue level, a hot topic in regenerative medicine. The overall aim of MAGPIEZ is to develop a novel platform to study mechanotransduction linked to Piezo1 channels in endothelial cells by remotely manipulating magnetic nanoparticles. A secondary goal is to validate the potential of this tool to stimulate signalling pathways related to cell proliferation in order to selectively boost angiogenesis. This can stand as a promising approach for therapeutic angiogenesis in ischemic disorders. This ambitious project will be validated using 2D endothelial cells and a 3D vascular network developed using a microfluidic chamber. MAGPIEZ is a highly multidisciplinary project that takes advantage of the Fellows Dr. Del Sol knowledge in Materials Science (advanced synthesis and characterization of magnetic nanoparticles, magnetism and physics) and the expertise of the host group supervisor (Dr. M. Moros, Institute of Nanoscience and Materials of Aragon INMA-CSIC) in biofunctionalization of nanoparticles and magnetogenetics. This project will offer the applicant the possibility to work in a top European institution who pioneered the use of nanomaterials for biomedical applications, and to develop new skills and knowledge necessary for the progress of her scientific career towards an independent position
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2021-PF-01
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
28006 MADRID
Spain
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.