Project description DEENESFRITPL Investigating how Piezo1 channels transform mechanical stimuli into biochemical signals The ability to remotely control intracellular pathways has opened the way to exciting applications both in the theoretical and experimental regime. The combined use of magnetic fields and magnetic nanoparticles serves as a powerful tool for studying how cells transform mechanical stimuli into biochemical signals. This process that is called mechanotransduction also allows manipulating biological functions with high spatiotemporal control at a deep-tissue level, which is relevant for regenerative medicine. Funded by the Marie Skłodowska-Curie Actions programme, the MAGPIEZ project plans to develop a novel platform to study mechanotransduction linked to Piezo1 channels in endothelial cells. Another goal is to validate the potential of this methodology to stimulate signalling pathways related to cell proliferation to selectively boost angiogenesis. Show the project objective Hide the project objective Objective During the last decade, the possibility to remotely control intracellular pathways using physical tools has opened the way to exciting applications, both in basic research and clinical applications. The use of magnetic fields in combination with magnetic nanoparticles provides with an exclusive tool to study how cells transform mechanical stimuli into biochemical signals, shedding light on these mechanotransduction processes. This tool is emerging as a new instrument to remotely manipulate biological functions with high spatiotemporal control at a deep-tissue level, a hot topic in regenerative medicine. The overall aim of MAGPIEZ is to develop a novel platform to study mechanotransduction linked to Piezo1 channels in endothelial cells by remotely manipulating magnetic nanoparticles. A secondary goal is to validate the potential of this tool to stimulate signalling pathways related to cell proliferation in order to selectively boost angiogenesis. This can stand as a promising approach for therapeutic angiogenesis in ischemic disorders. This ambitious project will be validated using 2D endothelial cells and a 3D vascular network developed using a microfluidic chamber. MAGPIEZ is a highly multidisciplinary project that takes advantage of the Fellow´s Dr. Del Sol knowledge in Materials Science (advanced synthesis and characterization of magnetic nanoparticles, magnetism and physics) and the expertise of the host group supervisor (Dr. M. Moros, Institute of Nanoscience and Materials of Aragon INMA-CSIC) in biofunctionalization of nanoparticles and magnetogenetics. This project will offer the applicant the possibility to work in a top European institution who pioneered the use of nanomaterials for biomedical applications, and to develop new skills and knowledge necessary for the progress of her scientific career towards an independent position Fields of science engineering and technologynanotechnologynano-materials Keywords magnetic nanoparticles magnetogenetics mechanotransduction Piezo1 Programme(s) HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA) Main Programme Topic(s) HORIZON-MSCA-2021-PF-01-01 - MSCA Postdoctoral Fellowships 2021 Call for proposal HORIZON-MSCA-2021-PF-01 See other projects for this call Funding Scheme HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships Coordinator AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS Net EU contribution € 181 152,96 Address CALLE SERRANO 117 28006 Madrid Spain See on map Region Comunidad de Madrid Comunidad de Madrid Madrid Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost No data Partners (1) Sort alphabetically Sort by Net EU contribution Expand all Collapse all BEONCHIP SL Spain Net EU contribution € 0,00 Address EDIFICIO CEMINEN SPINUP S/N, CALLE MARIANO ESQUILL CAMPUS UNIVERSITARIO RIO EBRO 50018 Zaragoza See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Noreste Aragón Zaragoza Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost No data