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Tunning the force for remote magnetomechanical gating of Piezo1 channels

Project description

Investigating how Piezo1 channels transform mechanical stimuli into biochemical signals

The ability to remotely control intracellular pathways has opened the way to exciting applications both in the theoretical and experimental regime. The combined use of magnetic fields and magnetic nanoparticles serves as a powerful tool for studying how cells transform mechanical stimuli into biochemical signals. This process that is called mechanotransduction also allows manipulating biological functions with high spatiotemporal control at a deep-tissue level, which is relevant for regenerative medicine. Funded by the Marie Skłodowska-Curie Actions programme, the MAGPIEZ project plans to develop a novel platform to study mechanotransduction linked to Piezo1 channels in endothelial cells. Another goal is to validate the potential of this methodology to stimulate signalling pathways related to cell proliferation to selectively boost angiogenesis.

Objective

During the last decade, the possibility to remotely control intracellular pathways using physical tools has opened the way to exciting applications, both in basic research and clinical applications. The use of magnetic fields in combination with magnetic nanoparticles provides with an exclusive tool to study how cells transform mechanical stimuli into biochemical signals, shedding light on these mechanotransduction processes. This tool is emerging as a new instrument to remotely manipulate biological functions with high spatiotemporal control at a deep-tissue level, a hot topic in regenerative medicine. The overall aim of MAGPIEZ is to develop a novel platform to study mechanotransduction linked to Piezo1 channels in endothelial cells by remotely manipulating magnetic nanoparticles. A secondary goal is to validate the potential of this tool to stimulate signalling pathways related to cell proliferation in order to selectively boost angiogenesis. This can stand as a promising approach for therapeutic angiogenesis in ischemic disorders. This ambitious project will be validated using 2D endothelial cells and a 3D vascular network developed using a microfluidic chamber. MAGPIEZ is a highly multidisciplinary project that takes advantage of the Fellow´s Dr. Del Sol knowledge in Materials Science (advanced synthesis and characterization of magnetic nanoparticles, magnetism and physics) and the expertise of the host group supervisor (Dr. M. Moros, Institute of Nanoscience and Materials of Aragon INMA-CSIC) in biofunctionalization of nanoparticles and magnetogenetics. This project will offer the applicant the possibility to work in a top European institution who pioneered the use of nanomaterials for biomedical applications, and to develop new skills and knowledge necessary for the progress of her scientific career towards an independent position

Coordinator

AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS
Net EU contribution
€ 181 152,96
Address
CALLE SERRANO 117
28006 Madrid
Spain

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Region
Comunidad de Madrid Comunidad de Madrid Madrid
Activity type
Research Organisations
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Total cost
No data

Partners (1)