Enabling Incompatible Tandem Reactions through Spatial Separation of Reaction Layers

Informations projet

ReLay

N° de convention de subvention: 101065137

DOI

10.3030/101065137

Projet clôturé

Date de signature de la CE 8 Juillet 2022

Date de début 1 Septembre 2022

Date de fin 31 Août 2024

Financé au titre de

• Marie Skłodowska-Curie Actions (MSCA)

Coût total

Aucune donnée

Contribution de l’UE

€ 189 687,36

Coordonné par

TECHNISCHE UNIVERSITAET MUENCHEN
Germany

Periodic Reporting for period 1 - ReLay (Enabling Incompatible Tandem Reactions through Spatial Separation of Reaction Layers)

Période du rapport: 2022-09-01 au 2024-08-31

Résumé du contexte et des objectifs généraux du projet

Today’s technology for the biocatalytic production of base chemicals is fossil-fuel based. Moving away from non-renewable and carbon-based energy feedstocks towards renewable hydrogen is a key challenge for current chemical processes. However, biocatalysis has yet to see H2 implemented as a energy source, simply because such H2-consuming reactions are sensitive to O2, whereas many enzymatic reactions driving product formation require O2 as a cosubstrate. H2-driven biocatalysis is not realized today on a large scale because of this need for both O2-sensitive and O2-dependent reactions to operate in tandem. The goal of this Marie Skłodowska-Curie individual fellowship project is to deliver the theoretical framework and experimental validation for novel biohybrid catalytic microdisks capable of carrying out seemingly incompatible tandem reactions by controlling the spatial separation of reaction layers (ReLay). These actions will create a universal platform for H2-driven biocatalysis, which can be implemented directly in current bioreactors.

Travail effectué depuis le début du projet jusqu’à la fin de la période considérée dans le rapport et principaux résultats atteints jusqu’à présent

Driven by both theory and simulation, the optimal conditions were found to create both anaerobic and aerobic domains allowing O2-sensitive and O2-dependent reactions to take place within a single particle. A reaction-diffusion model and simulation toolbox was built to establish the theoretical framework of spatially separated reaction layers in these catalytic micodisks. Second, the parameter space was explored using the model and simulations to find the best performing components and conditions.

Progrès au-delà de l’état des connaissances et impact potentiel prévu (y compris l’impact socio-économique et les conséquences sociétales plus larges du projet jusqu’à présent)

A new methodology for mapping the parameter space and identifying kinetic regimes of a general electrochemical system was developed. By introducing a geometric interpretation of kinetic zone diagrams, it was possible to automate the procedure for constructing zone diagrams using computational techniques. This allows for mapping the kinetic behavior of complex electrochemical systems encompassing chemical reactions coupled to mass transport and locating optimal kinetic regimes within large dimensional parameter spaces.

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