Objective
DILEMMA will orient fundamental research to fill a gap in diabetes mellitus (DM) biology, by addressing a relevant biomedical problem in a cross-disciplinary manner, with great societal and economic impact. I will use a unique combination of advanced nanoscopy with protein biochemistry and cell biology.
Clinical studies identified stiffening in vascular, muscle and connecting tissues as particular mechanical fingerprints for DM. In diabetic patients advanced glycation end products are clinical biomarkers of DM that correlate with increased heart failure risk, but the mechanism of action bridging the mechanical alterations at molecular and tissue levels remains elusive. Current techniques used to inspect biochemical regulation of proteins fall short at describing the interplay between their dynamics under force and biological function. An in-depth multiscale characterization of the mechanical landscape in DM is a promising approach to identify new mechanical biomarkers able to advance therapeutic and diagnostic strategies. DILEMMA will study the fundamental link between tissue stiffening and protein glycation modifications in DM at multiple scales relevant for mechanobiology. I will explore the hypothesis that in diabetic patients lamin proteins are modified by glycation, which disrupts nuclear mechanical homeostasis. DILEMMA will have a strong impact in DM biology by providing new tools to understand how protein glycation and nuclear mechanics set the mechanical properties of cells and tissues in pathophysiological conditions.
I will receive training and education to acquire or strengthen my technical, scientific, and soft skills. This action will impact my career, representing a jump that will advance my future goal of becoming an independent young leader and establishing a unique research line at national level. DILEMMA could improve future clinical practice and reduce economic burden on the health system.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules proteins
- medical and health sciences clinical medicine endocrinology diabetes
- medical and health sciences basic medicine physiology homeostasis
You need to log in or register to use this function
We are sorry... an unexpected error occurred during execution.
You need to be authenticated. Your session might have expired.
Thank you for your feedback. You will soon receive an email to confirm the submission. If you have selected to be notified about the reporting status, you will also be contacted when the reporting status will change.
Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
-
HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
See all projects funded under this programme
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
See all projects funded under this funding scheme
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2021-PF-01
See all projects funded under this callCoordinator
Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
28029 Madrid
Spain
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.