Objective
Virus infections cause a major healthcare burden worldwide. The neurotropic human herpes simplex virus 1 (HSV-1) establishes life-long latent infection in neurons, from which it frequently reactivates to disseminate within the population. Clinical complications caused by HSV-1 infections range from mild (herpes labialis) to sight- (keratitis) and even life-threatening diseases (encephalitis). Prevention and treatment of HSV-1 infections are considered a top priority by the WHO. However, development of vaccines and improved therapeutic approaches is hindered by our incomplete understanding of the virus-host interactions that govern infection and disease, especially the interplay between HSV-1 and intrinsic neuronal defenses. The highly conserved cellular RNA degradation pathway nonsense-mediated decay (NMD), which regulates expression of ~10% of cellular transcripts and controls numerous fundamental processes, has recently emerged as an important regulator of neuronal function. Based on my previous postdoctoral studies that revealed a major role for NMD in controlling infection by oncogenic human herpesviruses combined with my preliminary data on HSV-1, I hypothesize that NMD provides an intrinsic defense mechanism that controls HSV-1 infection. In this fellowship, I propose to combine my experience and the expertise of the host institute to determine the physiological relevance and molecular mechanism by which NMD controls HSV-1 infection in its natural human host. Successful completion of my project will lead to improved insight into the virus-host interactions that control infection of HSV-1, thereby providing novel therapeutic targets to combat HSV-1 infection and pathogenesis. Moreover, the extensive and multidisciplinary training in research and transferrable skills provided by this fellowship will be invaluable for my goal of becoming an all-round competitive scientist leading an independent research group focused on intrinsic immunity to neurotropic viruses.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences microbiology virology
- medical and health sciences basic medicine pharmacology and pharmacy pharmaceutical drugs vaccines
- natural sciences biological sciences genetics RNA
- medical and health sciences health sciences infectious diseases DNA viruses
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2021-PF-01
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
3015 GD Rotterdam
Netherlands
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.