Objective
NONCO-MICROTIS will combine new findings in long non-coding RNA (lncRNA) biology with cutting edge research to uncover innovative therapeutic opportunities for the treatment of lung cancer, one of the most prevalent and deadliest types of cancer worldwide. Current treatments which are often insufficient, include the use of chemotherapy and radiation that induces tumor cell arrest. This process termed as therapy-induced senescence (TIS) has been considered a positive outcome for cancer therapy. However, there is evidence that TIS can be reversible leading to an aggressive phenotype and disease relapse. The low percentage of senescent cells in the tumor together with the lack of specific markers senescence senescence has prevented the development of methods to identify and target this population of cells. I will exploit the highly specific expression patterns of lncRNAs by tailored single cell methods to identify therapy-induced senescent cells and their relationship with the tumor microenvironment. Further, NONCO-MICROTIS will investigate the senescence-related roles of small peptides produced by TIS-lncRNAs to be exploited for the targeting of these singular cells within lung tumors. Altogether my study will define a new senescence signature using specific lncRNAs that will help to identify senescent cells and will provide information on how these cells impact the neighbouring populations. Moreover, it will uncover mechanistic roles of micropeptides in the regulation and targeting of senescent cells and will provide the basis for the use of micropeptides as therapeutic targets.
NONCO-MICROTIS will combine cutting-edge techniques in transcriptomics and molecular and cellular biology techniques resulting in an original, multidisciplinary project with high potential for ground-breaking findings. Furthermore, it will allow me to reach the level of professional maturity needed to become an independent researcher.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules
- medical and health sciences clinical medicine oncology
- natural sciences biological sciences genetics RNA
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2021-PF-01
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
31008 Pamplona
Spain
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.