Objective
Stroke is the leading cause of disability and the third leading cause of death in the Western World. Over 50% of strokes occur in
asymptomatic patients and therefore better indicators of the disease are required. These acute asymptomatic cerebrovascular
events are due to vulnerable plaque rupture leading to thromboembolic events, stroke, and/or sudden death. From our work to-date
as part of ERC Starting grant FibreRemodel, we have found that that most significant contributor to rupture strength of a plaque is
the underlying collagen fibres within this tissue, particularly within the fibrous plaque cap. The underlying structure of the carotid
plaque may therefore be used to determine the risk of vulnerable plaque rupture. However, a non-invasive diagnostic technique,
which uses knowledge of in vivo arterial collagen content, has yet to be developed. VASCOLL will generate the first software tool
that can inform on plaque vulnerability in a non-invasive way, enabling early diagnosis of the predisposition of a carotid plaque to
rupture and facilitating the selection of the optimum treatment minimising the need for surgery and healthcare-associated costs.
This approach will offer a number of significant benefits over current approaches to vulnerable plaque identification. Firstly, this
technique will be the first ex vivo and in vivo application of the QSM technique to human arteries and carotid plaques to exploit the
sensitivity of magnetic susceptibility to collagen content in arteries. Secondly, this technique is relatively easy and efficient to
translate in vivo. Given that this method determines the underlying plaque and vessel structure, not merely level of stenosis,
VASCOLL will transform how vulnerable carotid plaques are identified and treated.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences clinical medicine surgery
- medical and health sciences basic medicine neurology stroke
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.1 - European Research Council (ERC)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-ERC-POC - HORIZON ERC Proof of Concept Grants
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) ERC-2022-POC1
See all projects funded under this callHost institution
Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
D02 CX56 Dublin
Ireland
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.