Project description
In vitro models of short bowel syndrome
Following extensive resection, the remaining small intestine may be of insufficient length to absorb nutrients, leading to short bowel syndrome (SBS). SBS is associated with significant malnutrition, and patients must take lifelong supplements. Funded by the Marie Skłodowska-Curie Actions programme, the SBS-microbe project aims to shed light on SBS pathogenesis, focusing on microbiota, metabolic and cellular changes occurring after resection. Researchers plan to develop in vitro models to study disease progression and the role of host−microbiota interactions. The identification of SBS drivers will unveil key targets for triggering intestinal homeostasis.
Objective
Short bowel syndrome (SBS) is a severe intestinal disorder that occurs in patients upon small bowel resection. While rare in prevalence, SBS severely affects the patients quality of life. SBS-microbe is a multidisciplinary translational project aimed at expanding our knowledge on SBS pathogenesis and the mechanisms for resection-induced physiological adaptations, through the identification of microbial, metabolic and cellular hallmarks. It integrates a combination of SHIME, as dynamic gastrointestinal (GI) model, with epithelial cellular models and in vivo patients data, to gain a better mechanistic insight in disease progression, severity and the interplay with the microbiota. It may additionally propose attractive therapeutic strategies and provide valuable tools to address physiological aspects for both healthy and pathological conditions, without the recourse to animal models. Hosted in the Center for Microbial Ecology and Technology at Ghent University, this proposal includes a secondment with SBS medical and metagenomics experts at KULeuven. The applicants microbiology and cell biology expertise will be expanded with reactor engineering skills, facilitating the development of novel in vitro models to address host-microbiota interactions in a simulated SBS environment. The secondment at KULeuven offers the opportunity to gain a better insight in cohort composition and identify determinants that potentially underlie the patients clinical condition, which is crucial for the mechanistic in vitro work.
Through the development of a GI and epithelial cellular models, SBS-microbe aims at identifying key microbial and cellular signatures occurring after intestinal resection. Additionally, this will enable the proof-of-concept that targeting specific microbial and metabolic markers may significantly empower the intestinal homeostasis in SBS and ameliorate the quality of life of these patients.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- natural sciences biological sciences ecology
- natural sciences biological sciences microbiology
- medical and health sciences basic medicine physiology homeostasis
You need to log in or register to use this function
We are sorry... an unexpected error occurred during execution.
You need to be authenticated. Your session might have expired.
Thank you for your feedback. You will soon receive an email to confirm the submission. If you have selected to be notified about the reporting status, you will also be contacted when the reporting status will change.
Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
-
HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
See all projects funded under this programme
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
See all projects funded under this funding scheme
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2021-PF-01
See all projects funded under this callCoordinator
Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
9000 Gent
Belgium
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.