Objective
Artificial metalloenzymes (ARMs), that is, designed enzymes containing a synthetic metal co-factor within a protein framework, locates itself as a promising area of research for the discovery and development of new transformations. We set our attention in cobalt complexes as co-factors, a first-row, earth-abundant, and non-toxic metal that is currently underexplored in ARMs. Cobalt complexes present a highly versatile chemistry, including they ability to participate in allylic functionalization reactions, an important transformation for the pharmaceutical industry as can deliver structural frameworks that are widely spread in biological active compounds. Allylic functionalization reactions are underdeveloped in bio-catalysis, and the expansion of important homogeneous reactions, as the before mentioned, into the realm of enzymes is an absolute necessity for the development of sustainable chemistry. Co-ARMs (Cobalt-containing ARtificial Metalloenzymes) proposal aims to create new generations of ARMs relying on the unique reactivity of synthetic cobalt complexes in allylic substitution reactions, an unknown reaction in enzyme catalysis and an underexplored metal for the discovery of new-to-nature reactions. The proposal balance between host expertise (Dr. Gerard Roelfes) in bio-inorganic and chemical biology, and the researchers skills (Dr. Franco Della-Felice) in synthetic organic chemistry. The result is a cooperative field where two different branches converge with the aim to develop new concepts and environmentally compatible tools in chemistry to access organic frameworks of high significance to the pharmaceutical and agrochemical industries.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences chemical sciences inorganic chemistry transition metals
- natural sciences chemical sciences catalysis biocatalysis
- natural sciences biological sciences biochemistry biomolecules proteins enzymes
You need to log in or register to use this function
We are sorry... an unexpected error occurred during execution.
You need to be authenticated. Your session might have expired.
Thank you for your feedback. You will soon receive an email to confirm the submission. If you have selected to be notified about the reporting status, you will also be contacted when the reporting status will change.
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
-
HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
See all projects funded under this programme
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
See all projects funded under this funding scheme
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2021-PF-01
See all projects funded under this callCoordinator
Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
9712CP Groningen
Netherlands
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.