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Deciphering rhinovirus-mediated macrophages impairment through the establishment of human induced pluripotent stem cells-derived macrophages

Project description

Mechanisms of virus-mediated macrophage response modulation

Viruses modulate myeloid cell responses, impairing macrophage phenotypes, and recent data suggest that this impairment can occur even without virus replication in these cells. Human rhinovirus (HRV) impairs macrophages’ responses to bacterial infection via downregulation of cytokine secretion. Understanding the mechanisms employed by viruses to modulate macrophages’ responses could offer therapeutic options to prevent virus-associated pathogenesis. Funded by the Marie Skłodowska-Curie Actions programme, the MacroRhino project aims to discover if HRV can replicate in alveolar macrophages and elucidate the HRV-mediated mechanisms of macrophage impairment. The researchers will develop a novel model of human lung alveolar macrophage-like cells derived from induced pluripotent stem cells to recapitulate organ physiology and the resident macrophage phenotype.

Coordinator

UNIVERSITE PARIS CITE
Net EU contribution
€ 195 914,88
Address
85 Bd Saint Germain
75006 Paris
France

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Region
Ile-de-France Ile-de-France Paris
Activity type
Higher or Secondary Education Establishments
Other funding
No data