Mechanisms of virus-mediated macrophage response modulation
Viruses modulate myeloid cell responses, impairing macrophage phenotypes, and recent data suggest that this impairment can occur even without virus replication in these cells. Human rhinovirus (HRV) impairs macrophages’ responses to bacterial infection via downregulation of cytokine secretion. Understanding the mechanisms employed by viruses to modulate macrophages’ responses could offer therapeutic options to prevent virus-associated pathogenesis. Funded by the Marie Skłodowska-Curie Actions programme, the MacroRhino project aims to discover if HRV can replicate in alveolar macrophages and elucidate the HRV-mediated mechanisms of macrophage impairment. The researchers will develop a novel model of human lung alveolar macrophage-like cells derived from induced pluripotent stem cells to recapitulate organ physiology and the resident macrophage phenotype.
Fields of science
- HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA) Main Programme