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The PomXYZ cluster in the bacterium Myxococcus xanthus: Self-assembly, translocation, and fission of an active protein complex that guides cell division

Project description

Theoretical modelling of cell division fundamental mechanisms

The mechanisms of precise cell division site positioning are incompletely understood. In the bacterium Myxococcus xanthus (Mx), the protein cluster PomX/Y/Z self-assembles on the nucleoid surface and translocates to the midcell to guide the division machinery in an ATP-dependent manner. Funded by the Marie Skłodowska-Curie Actions programme, the PomXYZ project will develop a theoretical model of the process, guiding the machinery for cell division to midcell in the Mx bacterium. During cell division, the Pom cluster undergoes fission, and the resulting clusters translocate to the midcell in daughter cells to induce further cell divisions. The researchers will employ a mesoscopic model, combining spatial dynamics with locally stimulated reactions, to study Pom cluster formation, translocation and fission.

Coordinator

LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN
Net EU contribution
€ 189 687,36
Address
Geschwister Scholl Platz 1
80539 Muenchen
Germany

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Region
Bayern Oberbayern München, Kreisfreie Stadt
Activity type
Higher or Secondary Education Establishments
Other funding
No data