Development of a first-in-class inhibitor of FIH for cancer immunotherapy

Informations projet

FIH-IO

N° de convention de subvention: 101069333

DOI

10.3030/101069333

Projet clôturé

Date de signature de la CE 12 Mai 2022

Date de début 1 Juin 2022

Date de fin 30 Novembre 2023

Financé au titre de

• European Research Council (ERC)

Coût total

Aucune donnée

Contribution de l’UE

€ 150 000,00

Coordonné par

ASOCIACION CENTRO DE INVESTIGACION COOPERATIVA EN BIOCIENCIAS
Spain

Periodic Reporting for period 1 - FIH-IO (Development of a first-in-class inhibitor of FIH for cancer immunotherapy)

Période du rapport: 2022-06-01 au 2023-11-30

Résumé du contexte et des objectifs généraux du projet

The project addresses a significant gap in current cancer treatment options by focusing on a novel approach to immunotherapy. Despite advances in immuno-oncology, current treatments like checkpoint receptor blockade are limited to a small subset of cancers and patient groups. Our laboratory is pioneering a treatment targeting the enzyme "Factor Inhibiting HIF" (FIH) to enhance the efficacy of immunotherapy, particularly for lung adenocarcinoma—a segment with dire medical need due to poor survival rates and limited therapeutic options. The project's goal is to improve treatment efficacy and to provide more affordable options. By developing this novel therapy and exploring technology transfer options, the project aims to significantly impact the quality of life for patients and reduce the economic burden on health systems.

Travail effectué depuis le début du projet jusqu’à la fin de la période considérée dans le rapport et principaux résultats atteints jusqu’à présent

The team has successfully identified and developed multiple selective inhibitors of FIH, ready for optimization and progress into a new class of immunotherapies. Through diverse scientific methodologies, including structural biology and medicinal chemistry, we have progressed from exploring the biology of FIH to hit identification. We have also validated our approach using transgenic mouse models and primary human T cells. The achievements so far represent promising steps toward a new, more effective treatment for cancer, with lung adenocarcinoma being the initial focus

Progrès au-delà de l’état des connaissances et impact potentiel prévu (y compris l’impact socio-économique et les conséquences sociétales plus larges du projet jusqu’à présent)

Our project is differentiated from current immuno-oncology treatments. The results have demonstrated that targeting FIH can inhibit lung cancer cell proliferation and potentiate the hypoxia response in T cells, offering a unique mechanism of action distinct from existing therapies. The potential impact is substantial, with the possibility of improving outcomes for a broad range of cancers. To ensure further success, continued research, investment in commercialization, and a supportive regulatory environment will be key. By project completion, we anticipate a comprehensive overview of the results that will support the transformative potential of this new therapy.