Developing a surgical infection treatment to reduce amputations, healing times and hospital stays for diabetic foot patients

Información del proyecto

XTremedy Medical

Identificador del acuerdo de subvención: 101069625

DOI

10.3030/101069625

Proyecto cerrado

Fecha de la firma de la CE 20 Junio 2022

Fecha de inicio 1 Julio 2022

Fecha de finalización 31 Diciembre 2022

Financiado con arreglo a

• European innovation ecosystems

Coste total

Sin datos

Aportación de la UE

€ 75 000,00

Coordinado por

XTREMEDY MEDICAL LIMITED
Ireland

Periodic Reporting for period 1 - XTremedy Medical (Developing a surgical infection treatment to reduce amputations, healing times and hospital stays for diabetic foot patients)

Período documentado: 2022-07-01 hasta 2022-12-31

Resumen del contexto y de los objetivos generales del proyecto

XTremedy Medical are a surgical device company developing treatments for infected wounds, in particular Diabetic Foot Ulcers (DFUs). Infection has now been recognised as a leading cause of wound chronicity - wounds that do not respond to initial treatments.i Infections that spread to deep muscle and bone tissues, are the leading cause of amputations in diabetics. Biofilms, a type of infection often found in wounds, are complex to treat with up to 1000-fold tolerance to antibiotics.ii High concentrations of antibiotics required to treat these infections impairs kidney function and leads to high rates of kidney failure.
XTremedy Medical overcomes limitations with current solutions by treating both surface and subsurface tissues without disrupting tissue structures. XTremedy’s first device – BioBlate, is a non-thermal ablation device using pulsed electric field ablation (PFA) to treat biofilms. PFA is known for its anti-microbial and non-destructive properties.
Incorporating BioBlate technology enables the surgeon to remove all biofilm within the wound without removing excess healthy tissue which impairs healing. Delivering wound margins free of biofilm leads to fewer surgeries and shortened hospital stays

Trabajo realizado desde el comienzo del proyecto hasta el final del período abarcado por el informe y los principales resultados hasta la fecha

Commercialisation (regulatory and market access) strategy mapped for BioBlate technology

Avances que van más allá del estado de la técnica e impacto potencial esperado (incluida la repercusión socioeconómica y las implicaciones sociales más amplias del proyecto hasta la fecha)

Xtremedy have demonstrated that thier PFA device is up to 1000x more effective at removing biofilm/bioburden than the standard of care (saline flush). Using the BioBlate device, the team achieved 6 log reductions in ex-vivo staph epidermis biofilms and 4 log reductions in staph aureus. This is compared to <1 log reduction with the standard of care, a saline flush. These results have been validated in a third party lab.