New Prime Editing and non-viral delivery strategies for Gene Therapy

Project Information

EdiGenT

Grant agreement ID: 101070903

DOI

10.3030/101070903

EC signature date 13 September 2022

Start date 1 October 2022

End date 30 September 2027

Funded under

• The European Innovation Council (EIC)

Total cost

€ 4 406 097,50

EU contribution

€ 4 406 097,50

Coordinated by

SORBONNE UNIVERSITE
France

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Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Data Management Plan (2)

Data Management Plan
Data Management Plan Update 1

Documents, reports (2)

Project management manual
Project templates and guidelines

Websites, patent fillings, videos etc. (1)

Project logo and website

Project logo and website are available

Publications

Peer reviewed articles (5)

Genetic Polymorphisms Associated with Fetal Hemoglobin (HbF) Levels and F-Cell Numbers: A Systematic Review of Genome-Wide Association Studies

Author(s): Coralea Stephanou, Stephan Menzel, Sjaak Philipsen, Petros Kountouris
Published in: International Journal of Molecular Sciences, Issue 25, 2025, ISSN 1422-0067
Publisher: MDPI AG
DOI: 10.3390/ijms252111408

A prime editing strategy to rewrite the γ-globin promoters and reactivate fetal hemoglobin for sickle cell disease

Author(s): Anne Chalumeau, Maria Bou Dames, Letizia Fontana, Simone Amistadi, Panagiotis Antoniou, Priyanka Loganathan, Margaux Mombled, Guillaume Corre, Martin Peterka, Mario Amendola, Carine Giovannangeli, Marcello Maresca, Annarita Miccio, Mégane Brusson
Published in: Blood, Issue 146, 2025, ISSN 0006-4971
Publisher: American Society of Hematology
DOI: 10.1182/BLOOD.2024028166

Emerging lipid–polymer hybrid nanoparticles for genome editing

Author(s): Mariana Gameiro; João F. Mano; Vítor M. Gaspar
Published in: Polymer Chemistry, Issue 15, 2024, ISSN 1759-9962
Publisher: The Royal Society of Chemistry
DOI: 10.1039/D4PY00298A

Enhanced γ-globin reactivation and sickle cell correction through a repressor-to-activator motif switch in the HBG1/2 promoters

Author(s): Anne Chalumeau, Panagiotis Antoniou, Maria Bou Dames, Pierre Martinucci, Elena Retana, Pragya Gupta, Mike Firth, Muralidhar Reddivari, Aathira Sarath Chandran, Jonathan S. Yen, Martin Peterka, Marcello Maresca, Mégane Brusson, Annarita Miccio
Published in: Molecular Therapy Nucleic Acids, Issue 37, 2026, ISSN 2162-2531
Publisher: Elsevier BV
DOI: 10.1016/J.OMTN.2026.102974

Reactivation of developmentally silenced globin genes through forced linear recruitment of remote enhancers

Author(s): Anna-Karina Felder, Sjoerd J. D. Tjalsma, Han J. M. P. Verhagen, Rezin Majied, Marjon J. A. M. Verstegen, Thijs C. J. Verheul, Jeffrey van Haren, Rebecca Mohnani, Richard Gremmen, Peter H. L. Krijger, Sjaak Philipsen, Emile van den Akker, Wouter de Laat
Published in: Blood, Issue 146, 2025, ISSN 0006-4971
Publisher: American Society of Hematology
DOI: 10.1182/BLOOD.2024028128