Project description DEENESFRITPL Innovative neuronavigational technology for brain surgery Neuronavigation enables neurosurgeons to avoid functional brain locations when removing tumours, using computer-assisted technologies. However, the inability to maintain accurate spatial information on lesions intraoperatively remains a challenge for brain tumour surgeries. The EU-funded HyperProbe project will assemble an interdisciplinary team to develop an innovative optical intraoperative imaging system based on hyperspectral imaging (HSI) and artificial intelligence (AI), for image reconstruction and molecular fingerprinting. The novel HSI system will be handheld and user-friendly, applying AI-based algorithms for the analysis and quantification of images. The project aims to validate the developed technology in vivo, using gold standard modalities in neuronavigational imaging, and provide final proof-of-principle during brain tumour surgery. Show the project objective Hide the project objective Objective In recent years, through the advancement of imaging technologies (such as MRI, PET, CT, among others) clinical localisation of lesions of the central nervous system (CNS) pre-surgery has made possible for neurosurgeons to plan and navigate away from functional brain locations when removing tumours. However, neuronavigation in the surgical management of brain tumours remains a significant challenge, due to the inability to maintain accurate spatial information of lesioned and non-lesioned locations intraoperatively. To answer this challenge, we have put together a team of engineers, physicists, data scientists and neurosurgeons to develop an innovative, all-optical intraoperative imaging system based on (i) hyperspectral imaging (HSI) for rapid, multi wavelength spectral acquisition, and (ii) artificial intelligence (AI) for image reconstruction and molecular fingerprint recognition. Our intraoperative HSI system (HyperProbe) will (1) map, monitor and quantify biomolecules of interest; (2) be handheld and user-friendly; (3) apply AI-based methods for the reconstruction of spectral images, the analysis of spatio-spectral data and the development and quantification of novel biomarkers. We will validate the developed capacity in phantoms, in vivo against gold standard modalities in neuronavigational imaging, and finally provide proof-of principle during brain tumour surgery. HyperProbe aims at providing functional and structural information on biomarkers of interest that is currently missing during neuro-oncological interventions. Fields of science natural sciencesbiological sciencesneurobiologynatural sciencescomputer and information sciencesartificial intelligencemedical and health sciencesclinical medicinesurgerynatural sciencesbiological sciencesbiochemistrybiomolecules Keywords Neuronavigation Neurosurgery Hyperspectral Imaging Functional Imaging Programme(s) HORIZON.3.1 - The European Innovation Council (EIC) Main Programme Topic(s) HORIZON-EIC-2021-PATHFINDERCHALLENGES-01-02 - Tools to measure and stimulate activity in Brain Tissue Call for proposal HORIZON-EIC-2021-PATHFINDERCHALLENGES-01 See other projects for this call Funding Scheme HORIZON-EIC - HORIZON EIC Grants Coordinator UNIVERSITA DEGLI STUDI DI FIRENZE Net EU contribution € 907 312,50 Address Piazza San Marco 4 50121 Florence Italy See on map Region Centro (IT) Toscana Firenze Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 907 312,50 Participants (7) Sort alphabetically Sort by Net EU contribution Expand all Collapse all EMOLED SOCIETA A RESPONSABILITA LIMITATA Italy Net EU contribution € 620 000,00 Address VIA DE BARDI 36 50125 Firenze See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Centro (IT) Toscana Firenze Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 620 000,00 TECHNISCHE UNIVERSITAET MUENCHEN Germany Net EU contribution € 496 137,50 Address Arcisstrasse 21 80333 Muenchen See on map Region Bayern Oberbayern München, Kreisfreie Stadt Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 496 137,50 UNIVERSITE LYON 1 CLAUDE BERNARD France Net EU contribution € 731 312,50 Address BOULEVARD DU 11 NOVEMBRE 1918 NUM43 69622 Villeurbanne Cedex See on map Region Auvergne-Rhône-Alpes Rhône-Alpes Rhône Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 762 562,50 Third-party Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure. CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS France Net EU contribution € 31 250,00 Address RUE MICHEL ANGE 3 75794 Paris See on map Region Ile-de-France Ile-de-France Paris Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 31 250,00 AZIENDA OSPEDALIERO-UNIVERSITARIA CAREGGI Italy Net EU contribution € 40 000,00 Address LARGO G.A. BRAMBILLA 3 50134 Firenze See on map Region Centro (IT) Toscana Firenze Activity type Research Organisations Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 227 500,00 EIBIR GEMEINNUTZIGE GMBH ZUR FORDERUNG DER ERFORSCHUNG DER BIOMEDIZINISCHEN BILDGEBUNG Austria Net EU contribution € 321 250,00 Address AM GESTADE 1 1010 Wien See on map Region Ostösterreich Wien Wien Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 321 250,00 HOSPICES CIVILS DE LYON France Net EU contribution € 213 562,50 Address QUAI DES CELESTINS 3 69002 Lyon See on map Region Auvergne-Rhône-Alpes Rhône-Alpes Rhône Activity type Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments) Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 213 562,50 Partners (1) Sort alphabetically Sort by Net EU contribution Expand all Collapse all UNIVERSITY COLLEGE LONDON United Kingdom Net EU contribution € 0,00 Address GOWER STREET WC1E 6BT London See on map Region London Inner London — West Camden and City of London Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost No data
