Mechanisms of co-translational assembly of multi-protein complexes

Project Information

CoTransComplex

Grant agreement ID: 101072047

DOI

10.3030/101072047

EC signature date 31 January 2023

Start date 1 April 2023

End date 31 March 2029

Funded under

• European Research Council (ERC)

Total cost

€ 9 458 525,00

EU contribution

€ 9 458 525,00

Coordinated by

RUPRECHT-KARLS-UNIVERSITAET HEIDELBERG
Germany

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (17)

Mechanisms and regulation of the Hsp70 chaperone network

Author(s): Anne Wentink, Rina Rosenzweig, Harm Kampinga, Bernd Bukau
Published in: Nature Reviews Molecular Cell Biology, Issue 27, 2026, ISSN 1471-0072
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/S41580-025-00890-9

The ribosome synchronizes folding and assembly to promote oligomeric protein biogenesis

Author(s): Alžběta Roeselová, Santosh Shivakumaraswamy, Gabija Jurkeviciute, Jessica Zhiyun He, Josef Auburger, Jaro L. Schmitt, Günter Kramer, Bernd Bukau, Radoslav I. Enchev, David Balchin
Published in: Molecular Cell, Issue 86, 2026, ISSN 1097-2765
Publisher: Elsevier BV
DOI: 10.1016/J.MOLCEL.2025.12.022

NAC promotes co-translational protein folding at the ribosomal tunnel exit

Author(s): Jaime Santos, Manuel Günnigmann, Radoslaw J. Gora, Marija Iljina, Masa Predin, Ilgin Eser Kotan, Pratiman De, Dhawal Choudhary, Juwon Jang, Frank Tippmann, Christopher Hins, Nenad Ban, Sander J. Tans, Shu-ou Shan, Günter Kramer, Bernd Bukau
Published in: Molecular Cell, Issue 86, 2026, ISSN 1097-2765
Publisher: Elsevier BV
DOI: 10.1016/J.MOLCEL.2026.02.022

Proteome-wide determinants of co-translational chaperone binding in bacteria

Author(s): Carla Verónica Galmozzi, Frank Tippmann, Florian Wruck, Josef Johannes Auburger, Ilia Kats, Manuel Guennigmann, Katharina Till, Edward P. O´Brien, Sander J. Tans, Günter Kramer, Bernd Bukau
Published in: Nature Communications, Issue 16, 2025, ISSN 2041-1723
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/S41467-025-59067-9

NAC controls cotranslational N-terminal methionine excision in eukaryotes

Author(s): Martin Gamerdinger, Min Jia, Renate Schloemer, Laurenz Rabl, Mateusz Jaskolowski, Katrin M. Khakzar, Zeynel Ulusoy, Annalena Wallisch, Ahmad Jomaa, Gundula Hunaeus, Alain Scaiola, Kay Diederichs, Nenad Ban, Elke Deuerling
Published in: Science, Issue 380, 2024, ISSN 0036-8075
Publisher: American Association for the Advancement of Science (AAAS)
DOI: 10.1126/SCIENCE.ADG3297

Mechanism of cotranslational protein N-myristoylation in human cells

Author(s): Martin Gamerdinger, Blanca Echeverria, Alfred M. Lentzsch, Nicolas Burg, Ziyi Fan, Mateusz Jaskolowski, Alain Scaiola, Selina Piening, Shu-ou Shan, Nenad Ban, Elke Deuerling
Published in: Molecular Cell, Issue 85, 2025, ISSN 1097-2765
Publisher: Elsevier BV
DOI: 10.1016/J.MOLCEL.2025.06.015

Distinct Cis-acting Elements Combinatorically Mediate Co-localization of mRNAs Encoding for Co-translational Interactors in Cytoplasmic Clusters in S. cerevisiae

Author(s): Qamar Shhade, Marianna E. Estrada, Rawad Hanna, Muhammad Makhzumy, Hagit Bar-Yosef, Guenter Kramer, Bernd Bukau, Ayala Shiber
Published in: Journal of Molecular Biology, Issue 438, 2026, ISSN 0022-2836
Publisher: Elsevier BV
DOI: 10.1016/J.JMB.2025.169546

SRP orchestrates protein biogenesis beyond initial ER membrane targeting

Author(s): Ilgın Eser Kotan, Sabrina Sartori, Rudra Bose, Bernd Bukau, Günter Kramer
Published in: Nature Communications, Issue 17, 2026, ISSN 2041-1723
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/S41467-026-74404-2

Modulation of Nudt21 levels reveals dose-dependent roles of alternative polyadenylation in tissue regeneration

Author(s): Nikolaos Tsopoulidis, Masaki Yagi, Justin Brumbaugh, Shinya Ito, Víctor López-Soriano, Robert Morris, Yoseop Yoon, Kathleen A. Messemer, Kuan-Hung Lin, Eric F. Zaniewski, Rebecca Gorelov, Aaron J. Huebner, Amy J. Wagers, Hanno Hock, Günter Kramer, Bernd Bukau, Michael S. Hoetker, Yongsheng Shi, Wilhelm Haas, Konrad Hochedlinger
Published in: Nature Communications, Issue 17, 2026, ISSN 2041-1723
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/S41467-026-68630-X

A highly optimized human in vitro translation system

Author(s): Adrian Bothe and Nenad Ban
Published in: Cell Reports Methods, Issue volume 4, issue 4, 2024, ISSN 2667-2375
Publisher: Elsevier
DOI: 10.1016/J.CRMETH.2024.100755

Co-translational ribosome pairing enables native assembly of misfolding-prone subunits

Author(s): Florian Wruck, Jaro Schmitt, Katharina Till, Kai Fenzl, Matilde Bertolini, Frank Tippmann, Alexandros Katranidis, Bernd Bukau, Günter Kramer, Sander J. Tans
Published in: Nature Communications, Issue 16, 2025, ISSN 2041-1723
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/S41467-025-61500-Y

NAC guides a ribosomal multienzyme complex for nascent protein processing

Author(s): Alfred M. Lentzsch; Denis Yudin; Martin Gamerdinger; Sowmya Chandrasekar; Laurenz Rabl; Alain Scaiola; Elke Deuerling; Nenad Ban; Shu-ou Shan
Published in: Nature, 2024, ISSN 1476-4687
Publisher: Springer Nature
DOI: 10.1038/S41586-024-07846-7

A simple, fast and cost-efficient protocol for ultra-sensitive ribosome profiling

Author(s): Jiri Koubek; Katharina Jetzinger; Shiran Dror; Mikel Irastortza-Olaziregi; Dana Frank; Ilgin Kotan; Jaime Santos; Frank Tippmann; Pascal Lafrenz; Henrik Kaessmann; Orna Amster-Choder; Bernd Bukau; Günter Kramer
Published in: Nucleic Acids Research, 2025, ISSN 1362-4962
Publisher: Oxford Academic
DOI: 10.1101/2025.04.09.647970

Trigger factor accelerates nascent chain compaction and folding

Author(s): Katharina Till, Anne-Bart Seinen, Florian Wruck, Vanda Sunderlikova, Carla V. Galmozzi, Alexandros Katranidis, Bernd Bukau, Günter Kramer, Sander J. Tans
Published in: Proceedings of the National Academy of Sciences, Issue 122, 2025, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/PNAS.2422678122

Cotranslational Assembly of Oligomeric Proteins

Author(s): Jaime Santos, Sander J. Tans, Nenad Ban, Günter Kramer, Bernd Bukau
Published in: Annual Review of Biochemistry, Issue 95, 2026, ISSN 0066-4154
Publisher: Annual Reviews
DOI: 10.1146/ANNUREV-BIOCHEM-051024-124747

Mechanism of cotranslational modification of histones H2A and H4 by MetAP1 and NatD

Author(s): Denis Yudin, Mateusz Jaskolowski, Ziyi Fan, Nicolas Burg, Sowmya Chandrasekar, Alfred M. Lentzsch, Alain Scaiola, Adrian Bothe, Elke Deuerling, Martin Gamerdinger, Shu-ou Shan, Nenad Ban
Published in: Science Advances, Issue 11, 2025, ISSN 2375-2548
Publisher: American Association for the Advancement of Science (AAAS)
DOI: 10.1126/SCIADV.AEB1017

Chp1 is a dedicated chaperone at the ribosome that safeguards eEF1A biogenesis

Author(s): Melania Minoia, Jany Quintana-Cordero, Katharina Jetzinger, Ilgin Eser Kotan, Kathryn Jane Turnbull, Michela Ciccarelli, Anna E. Masser, Dorina Liebers, Eloïse Gouarin, Marius Czech, Vasili Hauryliuk, Bernd Bukau, Günter Kramer, Claes Andréasson
Published in: Nature Communications, Issue 15, 2024, ISSN 2041-1723
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/S41467-024-45645-W