Project description
Innovative combination therapy for metastatic melanoma
Treatment of metastatic melanoma requires a combination of therapies for efficient cancer cell eradication. Physical barriers of cellular and non-cellular origin in the tumour microenvironment, abnormal tumour vasculature and high interstitial fluid pressure prevent tumour infiltration by chimeric antigen receptor (CAR)-T cells used in immunotherapy. Funded by the Marie Skłodowska-Curie Actions programme, the Melomanes project aims to train researchers in the development of a combined therapy approach using magnetic nanoparticles to induce magnetic and optic hyperthermia damage in the tumour microenvironment, facilitating infiltration by CAR-T cells. The developed treatment approach combining hyperthermia and immunotherapy will be versatile in terms of application to other types of solid tumours.
Objective
Metastatic melanoma is a hard-to-treat disease and it remains as one of the most worrisome cancer. There is an urgent need to improve the current therapies (chemotherapy, radiotherapy) that have a limited efficacy. A single therapy is not efficient to tackle metastatic melanoma and a combination of therapies is thus emerging as a necessity to efficiently eradicate all cancer cells. Recently, the development of immunotherapies has shown promises, in particular chimeric antigen receptor (CAR)-T cells. Nevertheless, the physical barriers represented by cellular and non-cellular components of the tumor microenvironment combined to the abnormal tumor vasculature and high interstitial fluid pressure, hamper an efficient tumour infiltration of CAR-T cells. In this context, thanks to a network of 18 partners (including 10 non-academic partners), MELOMANES aims to train doctoral researchers for the development of a combined therapy exploiting the properties of magnetic nanoparticles to induce damage on the tumor microenvironment by magnetic and optic hyperthermia in order to facilitate the infiltration of CAR-T cells. This therapeutic approach combining hyperthermia and immunotherapy is versatile, as it could be also applied to other types of solid tumors. Research and transferable training of the doctoral researchers will be performed in a highly interdisciplinary, intersectoral, and international environment. In addition to acquiring skills related to the research project, they will be trained also in open science, communication and dissemination, responsible research and innovation, circular economy, ethics, data management, entrepreneurship, marketing, intellectual property, and gender dimension in research. Their competences will be validated through certification and qualification examination, allowing a new generation of highly skilled doctoral researchers to emerge with a high-level training in particular in the multidisciplinary field of nanomedicine.
Fields of science
Keywords
Programme(s)
- HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA) Main Programme
Funding Scheme
HORIZON-TMA-MSCA-DN - HORIZON TMA MSCA Doctoral NetworksCoordinator
75794 Paris
France
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Participants (7)
1010 Wien
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1070 Nicosia
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
20520 Turku
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
39011 Santander
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75015 Paris
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
0450 Oslo
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1081 HV Amsterdam
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Partners (17)
Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
8600 Dubendorf
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75654 Paris
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08193 Cerdanyola Del Valles
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Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
ST5 5NL Keele Newcastle Under Lyme
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
3001 Leuven
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
1060 Wien
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
1250-148 Lisboa
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Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
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Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
3500 Krems An Der Donau
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
8092 Zuerich
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Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
20014 Turku
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Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
2121 Nicosia
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Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
39005 Santander
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Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
0313 Oslo
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Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
67081 Strasbourg
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Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
75006 Paris
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Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
OX9 3EZ Thame
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