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Greener, more sustainable platforms for high-value recombinant protein production

Project description

DEENESFRITPL

Innovative platforms for high-quality recombinant protein production

Secreted high-quality recombinant proteins, especially industrial enzymes and therapeutic proteins (biotherapeutics) are significant for healthcare and a sustainable bio-based economy. However, recombinant protein production is mainly carried out in high-income countries, resulting in inequality in the biotechnology sector. The EU-funded greenerRPP project will address the rapidly emerging issue of 'sustainability' in the European biotechnology industry by developing powerful new microbial and mammalian cell platforms that produce recombinant proteins in unusually high quantities and unparalleled quality. The project will improve yield and process design to increase the industry's effectiveness and reduce high levels of waste and reduce energy and raw material costs in countless industrial and domestic settings.

Objective

The greenerRPP project aims to markedly enhance the EU’s capacity for the production of secreted high-quality recombinant proteins, especially industrial enzymes and therapeutic proteins (biotherapeutics). The combined markets are in excess of $330 billion p.a. and the products are of massive significance for healthcare and a sustainable bio-based economy. greenerRPP will address urgent problems in these industries, such as difficult-to-express proteins and the rapidly-emerging issue of 'sustainability' in the European biotechnology industry. It will deliver improvements in yield and process design that increase the industry's effectiveness while simultaneously reducing high current levels of waste. It will deliver industrial enzymes that reduce energy and raw material costs in countless industrial and domestic settings. To achieve this, we will develop powerful new microbial and mammalian cell platforms that produce recombinant proteins in unusually high quantities and in unparalleled quality, and bring to market a suite of super-producing platforms.
A comprehensive training programme will equip greenerRPP ESRs with the interdisciplinary and intersectoral skills required to be future leaders in these industries, while emphasising sustainability and gender-diversity dimension principles at every level. Finally, the programme addresses the stark global inequality in this biotechnology sector: recombinant protein production is largely carried out in (or outsourced by) high-income countries, placing low/middle income countries at a massive disadvantage. greenerRPP includes a series of South East Asian Institutions as Associated Partners, to develop a global network with a knowledge exchange-secondment programme that boosts these countries' own manufacturing programmes. greenerRPP ESRs will thus enhance a European industrial sector that has never been more important to society, while making it 'greener' and reaching out to lower income countries.

Fields of science

Programme(s)

Topic(s)

Call for proposal

HORIZON-MSCA-2021-DN-01

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Funding Scheme

HORIZON-AG-UN - HORIZON Unit Grant

Coordinator

ACADEMISCH ZIEKENHUIS GRONINGEN
Net EU contribution
€ 685 926,00
Address
Hanzeplein 1
9713 GZ Groningen
Netherlands

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Region
Noord-Nederland Groningen Overig Groningen
Activity type
Higher or Secondary Education Establishments
Links
Other funding
€ 0,00

Participants (6)

Partners (8)

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EC signature date 22 June 2022
Last update: 23 August 2022

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Permalink: https://cordis.europa.eu/project/id/101073056

European Union, 2023