Green and digital continuous-flow pharmaceutical manufacturing

Project Information

GreenDigiPharma

Grant agreement ID: 101073089

DOI

10.3030/101073089

EC signature date 6 July 2022

Start date 1 January 2023

End date 31 December 2026

Funded under

• Marie Skłodowska-Curie Actions (MSCA)

Total cost

No data

EU contribution

€ 2 605 881,60

Coordinated by

POLITECNICO DI MILANO
Italy

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Deliverables

Websites, patent fillings, videos etc. (1)

Website

Website, Twitter and Instagram accounts

Publications

Peer reviewed articles (19)

Azabicyclo[1.1.0]butyl‐Substituted Sulfonimidoyl Fluoride: Electrophilic Hub Bridging Late‐Stage Azetidine Incorporation with Sufex Chemistry

Author(s): Defne Serbetci; Philipp Natho; Ernesto Mesto; Emanuela Schingaro; Marco Colella; Renzo Luisi
Published in: Advanced Synthesis & Catalysis, 2025, ISSN 1615-4169
Publisher: Wiley-VCH GmbH
DOI: 10.1002/ADSC.70049

Nature Communications

Author(s): Miguel M. de Vries Ibáñez; Luis A. Cipriano; Valeria Lagostina; Andrea Olivati; Mario Chiesa; Annamaria Petrozza; Giovanni Di Liberto; Gianvito Vilé
Published in: Nature Communications, 2025, ISSN 2041-1723
Publisher: Springer Nature
DOI: 10.1038/S41467-025-61639-8

Light-driven and green Ullmann homocoupling with a Pd single-atom catalyst

Author(s): Areti Moutsiou; Theodore A. Gazis; Luis A. Cipriano; Mert Can Ince; Ik Seon Kwon; Nicolò Allasia; Sadaf Fatima Jafri; Elisa Borfecchia; Lorenzo Mino; Martin Sterrer; Giovanni Di Liberto; Gianvito Vilé
Published in: Green Chemistry, 2026, ISSN 1463-9270
Publisher: Royal Society of Chemistry (RSC)
DOI: 10.1039/D5GC04693A

Electrosynthesis of Aryliminophosphoranes in Continuous Flow

Author(s): Rodrigo Costa e Silva, Clara Vega, Morgan Regnier, Luca Capaldo, Lars Wesenberg, Grace Lowe, Kleber Thiago de Oliveira, Timothy Noël
Published in: Advanced Synthesis & Catalysis, Issue 366, 2025, ISSN 1615-4150
Publisher: Wiley
DOI: 10.1002/ADSC.202300635

Rapid and scalable photocatalytic C(sp2)–C(sp3) Suzuki−Miyaura cross-coupling of aryl bromides with alkyl boranes

Author(s): Ting Wan, Luca Capaldo, Jonas Djossou, Angela Staffa, Felix J. de Zwart, Bas de Bruin, Timothy Noël
Published in: Nature Communications, Issue 15, 2024, ISSN 2041-1723
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/S41467-024-48212-5

3D printed C₃N₄-based structures for photo-, electro-chemical and piezoelectric applications

Author(s): Alessio Massaro; Kiem Giap Nguyen; David Vogelsang Suárez; Artem Glukharev; Chiara Ingrosso; Marinella Striccoli; Ahmet Can Kirlioglu; Suela Kellici; Vesna Middelkoop
Published in: Materials Chemistry Frontiers, 2025, ISSN 2052-6834
Publisher: Royal Society of Chemistry
DOI: 10.1039/D5QM00290G

Generation and Use of Cyclopropenyllithium under Continuous Flow Conditions

Author(s): Francesco Soddu; Iktedar Mahdi; Maria Chiara Cabua; Francesco Secci; Philipp Natho; Riccardo Tassoni; Paolo Dambruoso; Ernesto Mesto; Marco Colella; Renzo Luisi
Published in: Organic Letters, 2025, ISSN 1523-7052
Publisher: American Chemical Society (ACS)
DOI: 10.1021/ACS.ORGLETT.5C01516

ACS Sustainable Chemistry and Engineering

Author(s): Marko Božinović; Marjan Jereb; Borut Šketa; Aljaž Gaber; Mojca Seručnik; Janez Košmrlj; Polona Žnidaršič-Plazl
Published in: ACS Sustainable Chemistry & Engineering, 2025, ISSN 2168-0485
Publisher: American Chemical Society
DOI: 10.1021/ACSSUSCHEMENG.5C04752

Flow Electroreductive Nickel‐Catalyzed Cyclopropanation of Alkenes Using <i>gem</i>‐Dichloroalkanes

Author(s): Morgan Regnier, Clara Vega, Dimitris I. Ioannou, Zhenyu Zhang, Timothy Noël
Published in: Angewandte Chemie International Edition, 2025, ISSN 1433-7851
Publisher: Wiley
DOI: 10.1002/ANIE.202500203

Sustainability and Techno-Economic Assessment of Batch and Flow Chemistry in Seven Industrial Pharmaceutical Processes

Author(s): Mert Can Ince, Brahim Benyahia, Gianvito Vilé
Published in: ACS Sustainable Chemistry &amp; Engineering, 2025, ISSN 2168-0485
Publisher: American Chemical Society (ACS)
DOI: 10.1021/ACSSUSCHEMENG.4C09289

Enhancing electrochemical reactions in organic synthesis: the impact of flow chemistry

Author(s): Morgan Regnier, Clara Vega, Dimitris I. Ioannou, Timothy Noël
Published in: Chemical Society Reviews, Issue 53, 2024, ISSN 0306-0012
Publisher: Royal Society of Chemistry (RSC)
DOI: 10.1039/D4CS00539B

Visible light-induced halogen-atom transfer by N-heterocyclic carbene-ligated boryl radicals for diastereoselective C(sp³)–C(sp²) bond formation

Author(s): Luca Capaldo, Ting Wan, Robin Mulder, Jonas Djossou, Timothy Noël
Published in: Chemical Science, Issue 15, 2024, ISSN 2041-6520
Publisher: Royal Society of Chemistry (RSC)
DOI: 10.1039/D4SC02962C

ACS Sustainable Chemistry and Engineering

Author(s): Marko Božinović; Marjan Jereb; Borut Šketa; Aljaž Gaber; Mojca Seručnik; Janez Košmrlj; Polona Žnidaršič-Plazl
Published in: ACS Sustainable Chemistry &amp; Engineering, Issue 13, 2025, ISSN 2168-0485
Publisher: American Chemical Society
DOI: 10.1021/ACSSUSCHEMENG.5C04752

1‐Oxa‐2,6‐Diazaspiro[3.3]heptane as a New Potential Piperazine Bioisostere – Flow‐Assisted Preparation and Derivatisation by Strain‐Release of Azabicyclo[1.1.0]butanes

Author(s): Elena Graziano, Philipp Natho, Michael Andresini, Fabrizio Mastrolorito, Iktedar Mahdi, Ernesto Mesto, Marco Colella, Leonardo Degennaro, Orazio Nicolotti, Renzo Luisi
Published in: Advanced Synthesis &amp; Catalysis, 2024, ISSN 1615-4150
Publisher: Wiley
DOI: 10.1002/ADSC.202400781

A Practical Guide to SuFEx Chemistry: An Overview of S(VI)-SuFEx Linkers and Their Reactivity

Author(s): Defne Serbetci, Laura Marraffa, Renzo Luisi, Philipp Natho, Michael Andresini
Published in: Synthesis, 2024, ISSN 0039-7881
Publisher: Georg Thieme Verlag KG
DOI: 10.1055/A-2410-2039

Continuous Flow Decarboxylative Monofluoroalkylation Enabled by Photoredox Catalysis

Author(s): Francesco Pasca, Yuri Gelato, Michael Andresini, Defne Serbetci, Philipp Natho, Giuseppe Romanazzi, Leonardo Degennaro, Marco Colella, Renzo Luisi
Published in: JACS Au, 2025, ISSN 2691-3704
Publisher: American Chemical Society (ACS)
DOI: 10.1021/JACSAU.4C00902

Sustainable upgrading of glycerol into glycidol and its derivatives under continuous-flow conditions

Author(s): Alessandra Sivo, Ilaria Montanari, Mert Can Ince, Gianvito Vilé
Published in: Green Chemistry, Issue 26, 2024, ISSN 1463-9262
Publisher: Royal Society of Chemistry (RSC)
DOI: 10.1039/D4GC01565G

Synthesis of Aza‐S(VI) Fluorides and Primary Sulfonimidamides from Sulfinylamines

Author(s): Michael Andresini, Laura Marraffa, Defne Şerbetçi, Philipp Natho, Marco Colella, Leonardo Degennaro, Renzo Luisi
Published in: Advanced Synthesis &amp; Catalysis, Issue 367, 2025, ISSN 1615-4150
Publisher: Wiley
DOI: 10.1002/ADSC.202400908

Towards greener-by-design fine chemicals. Part 2: technological frontiers

Author(s): Theodore A. Gazis; Rodolfo I. Teixeira; Giulio Volpin; Ashish Yewale; Mert Can Ince; Mark J. Ford; Jan Harmsen; Marco Uboldi; Alice Melocchi; Mattia Sponchioni; Andrea Aramini; Renzo Luisi; Brahim Benyahia; Gianvito Vilé
Published in: Chemical Society Reviews, 2026, ISSN 1460-4744
Publisher: Royal Society of Chemistry (RSC)
DOI: 10.1039/D5CS00930H