Objectif
RNA-binding proteins (RBPs) are critical regulators of gene expression programs. They regulate all aspects of RNA life, including transcription, splicing, modification, localization, stability, translation and decay, and consequently, perturbations in these RBP-RNA networks underlie the origin of many diseases. Recent proteomics-based studies have vastly expanded the repertoire of RBPs to the thousands, uncovering unconventional RBPs such as metabolic enzymes ‘moonlighting’ in RNA-binding activity or RNAs “riboregulating” protein function. This represents a much broader layer of biological control that was previously envisaged, which adds an entirely new dimension to RBP-dependent regulation of cellular homeostasis. RBP-ReguNet has been conceived to leverage these new discoveries to identify druggable targets for a range of untreatable diseases, including cancer, neurological disorders, liver diseases and infectious disease. Our ambition in RBP-ReguNet is to create a high-level training program based on basic research but with a strong impact on clinical translation. RBP-ReguNet will provide advanced multidisciplinary scientific training that spans from computational, structural, molecular and cellular biology to medicinal chemistry and pharmacological screening, to the next generation of European researchers in an intersectoral environment to pursue ambitious and high gain research on the development of new therapies based on RBP biology. They will be trained in a range of core and state-of-the-art discipline-specific research skills, complementary transferable skills, and entrepreneurial skills by secondments to non-academic partners, with a common focus to discover actionable targets. This network of excellence will push the boundaries of knowledge in the protein-RNA interactions universe, and at the same time provide the next generation of students with the skills to become future leaders in the field.
Champ scientifique
Mots‑clés
Programme(s)
- HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA) Main Programme
Régime de financement
HORIZON-TMA-MSCA-DN - HORIZON TMA MSCA Doctoral NetworksCoordinateur
15782 Santiago De Compostela
Espagne
Voir sur la carte
Participants (7)
08003 Barcelona
Voir sur la carte
75231 Paris
Voir sur la carte
38123 Trento
Voir sur la carte
L’entreprise s’est définie comme une PME (petite et moyenne entreprise) au moment de la signature de la convention de subvention.
69117 Heidelberg
Voir sur la carte
20122 Milano
Voir sur la carte
38122 Trento
Voir sur la carte
1006 AN Amsterdam
Voir sur la carte
Partenaires (7)
15706 Santiago De Compostela
Voir sur la carte
00185 Roma
Voir sur la carte
94800 Villejuif
Voir sur la carte
08002 Barcelona
Voir sur la carte
91190 Gif-Sur-Yvette
Voir sur la carte
G12 8QQ Glasgow
Voir sur la carte
1012WX Amsterdam
Voir sur la carte